and are types of microbiota that live in the gastrointestinal (GI) system, or gut microbiota, and are essential for both human well-being and disease. This review looks at the relationship between the composition of gut microbiota and function and two important lifestyle factors - dietary intake and sleep disorders. The diversity of the gut microbiota and metabolic processes is strongly influenced by food intake. Fiber-rich diets encourage the development of good bacteria that synthesize short-chain fatty acids (SCFA), while diets heavy in fat or sugar can negatively impact the microbial balance. Microbial communities are also impacted by regular meal schedules and probiotic and prebiotic use. Sleep disturbances cause stress reactions that alter gut microbiota and upset circadian rhythms. These include irregular sleep cycles and insomnia. These effects are driven by the immune system and gut-brain axis dysregulation, which affects microbial diversity and plays a role in GI and metabolic illnesses. The significance of comprehensive lifestyle treatments to improve gut health is highlighted by an understanding of these interconnections. It may be possible to modify the composition of gut microbiota and improve general health outcomes through the use of strategies that emphasize balanced meals, consistent eating schedules, and better sleep hygiene.
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http://dx.doi.org/10.7759/cureus.70846 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Biochemistry & Molecular Biology, University of Georgia, Athens, GA 30602.
is a dominant member of the human gut microbiome and produces short-chain fatty acids (SCFAs). These promote immune system function and inhibit inflammation, making this microbe important for human health. Lactate is a primary source of gut SCFAs but its utilization by has not been explored.
View Article and Find Full Text PDFPLoS One
January 2025
Center of Excellence in Probiotics, Srinakharinwirot University, Bangkok, Thailand.
Modern treatment, a healthy diet, and physical activity routines lower the risk factors for metabolic syndrome; however, this condition is associated with all-cause and cardiovascular mortality worldwide. This investigation involved a randomized controlled trial, double-blind, parallel study. Fifty-eight participants with risk factors of metabolic syndrome according to the inclusion criteria were randomized into two groups and given probiotics (Lacticaseibacillus paracasei MSMC39-1 and Bifidobacterium animalis TA-1) (n = 31) or a placebo (n = 27).
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Older individuals experience increased susceptibility and mortality to bacterial infections, but the underlying etiology remains unclear. Herein, it is shown that aging-associated reduction of commensal Parabacteroides goldsteinii (P. goldsteinii) in both aged mice and humans critically contributes to worse outcomes of bacterial infection.
View Article and Find Full Text PDFJ Cancer Res Ther
December 2024
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, China.
Tumor-infiltrating lymphocytes (TILs) are key components of the tumor microenvironment (TME) and serve as prognostic markers for breast cancer. Patients with high TIL infiltration generally experience better clinical outcomes and extended survival compared to those with low TIL infiltration. However, as the TME is highly complex and TIL subtypes perform distinct biological functions, TILs may only provide an approximate indication of tumor immune status, potentially leading to biased prognostic results.
View Article and Find Full Text PDFJ Cancer Res Ther
December 2024
Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan, China.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most important methods for treating a wide range of hematologic malignancies and bone marrow failure diseases. However, graft-versus-host disease (GVHD), a major complication associated with this method, can seriously affect the survival and quality of life of patients. Acute GVHD (aGVHD) occurs within 100 days after transplantation, and gastrointestinal aGVHD (GI-aGVHD) is one of the leading causes of nonrecurrent death after allo-HSCT.
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