AI Article Synopsis
- Strains of sequence type (ST) 37, especially PCR ribotype (RT) 017, are common in mainland China, prompting a study on their virulence factors.
- The study involved comparing an epidemic isolate (Xy06) from China to two reference strains (R20291 and CD630E) and another local strain (Xy07), noting key genomic features and virulence traits.
- Results indicated that Xy06 exhibited stronger virulence compared to Xy07 and CD630E and was on par with R20291, highlighting the potential threat posed by ST37 strains in the region.
Article Abstract
strains of sequence type (ST) 37, primarily including PCR ribotype (RT) 017, are prevalent in mainland China. Our study aimed to compare the major virulence factors of an epidemic isolate of ST37 type (Xy06) from China with the well-characterized reference strains R20291 (RT027) and CD630E (ST54), as well as a Chinese ST54 strain (Xy07) isolated from the same hospital. The Xy06 genome was predicted to harbor two complete prophages and several transposon-like elements. Comparative analysis of PaLoc revealed a truncated tcdA gene, a functional tcdB gene, a functional tcdC gene, and well-conserved tcdR and tcdE genes. Phenotypic comparisons showed that Xy06 was a robust producer of TcdB, readily sporulated and germinated, and strongly bound to human gut epithelial cells. In a mouse model of infection, Xy06 was more virulent than strains CD630E and Xy07 and was comparable to strain R20291 in virulence. Our data suggest the potential threat of the epidemic ST37 strains in China.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527712 | PMC |
| http://dx.doi.org/10.3389/fcimb.2024.1412408 | DOI Listing |
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