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Heart failure outcomes captured by adverse event reporting in participants with type 2 diabetes and atherosclerotic cardiovascular disease: Observations from the VERTIS CV trial.
Eur J Heart Fail
January 2025
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aims: In VERTIS CV, ertugliflozin was associated with a 30% risk reduction for adjudication-confirmed, first and total hospitalizations for heart failure (HHF) in participants with type 2 diabetes and atherosclerotic cardiovascular disease. We evaluated the impact of ertugliflozin on the broader spectrum of all reported heart failure (HF) events independent of adjudication confirmation.
Methods And Results: Data from participants who received ertugliflozin (5 or 15 mg) were pooled and compared versus placebo.
Long-term effects of linear versus macrocyclic GBCAs on gene expression in the central nervous system of mice.
Eur Radiol Exp
January 2025
Laboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background: We examined chronic gadolinium retention impact on gene expression in the mouse central nervous system (CNS) after injection of linear or macrocyclic gadolinium-based contrast agents (GBCAs).
Methods: From 05/2022 to 07/2023, 36 female mice underwent weekly intraperitoneal injections of gadodiamide (2.5 mmol/kg, linear), gadobutrol (2.
Age-specific and sex-specific associations of visceral adipose tissue with metabolic health status and cardiovascular disease risk.
Acta Diabetol
January 2025
Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China.
Background: Visceral adipose tissue (VAT) is known to play a role in the development of metabolic and cardiovascular disease (CVD). However, the age- and sex-specific associations between VAT and these diseases remain unclear.
Methods: In this cross-sectional study, 1,150 participants (39.
Impact of the Electrode Material on the Performance of Light-Emitting Electrochemical Cells.
ACS Appl Mater Interfaces
January 2025
The Organic Photonics and Electronics Group, Department of Physics, Umeå University, SE-90187 Umeå, Sweden.
Light-emitting electrochemical cells (LECs) are promising candidates for fully solution-processed lighting applications because they can comprise a single active-material layer and air-stable electrodes. While their performance is often claimed to be independent of the electrode material selection due to the in situ formation of electric double layers (EDLs), we demonstrate conceptually and experimentally that this understanding needs to be modified. Specifically, the exciton generation zone is observed to be affected by the electrode work function.
View Article and Find Full Text PDFWaist circumference and altered metabolic indices are associated with increased resting pulse rate in middle-aged adults.
Monaldi Arch Chest Dis
January 2025
Faculty of Medicine, The University of Jordan, Amman.
Metabolic indices significantly impact cardiovascular health. Research on the influence of metabolic indices on resting pulse rate in younger adults is needed. Utilizing the National Longitudinal Study of Adolescent to Adult Health (Add Health) Wave 5 Public-use biological data, we performed a multiple linear regression analysis to determine the predictive factors of resting pulse rate in adults aged 32-42 years.
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