A bifunctional luminescence sensor for biomarkers detection in serum and urine based on chemorobust Nickel(II) metal-organic framework.

The rapid detection of biomarkers in bodily fluids is vital for clinical diagnosis and regular disease monitoring. In this work, a mixed-ligand strategy was employed to successfully construct a nickel(II) metal-organic framework ([Ni(HTPTC)(bib)(HO)], NiMOF). Outstanding thermal and chemical stabilities coupled with the favorable luminescent performances endow NiMOF significant potential as an ideal bifunctional luminescence sensor with high selectivity and sensitivity, exceptional anti-interferences and recyclable performances, as well as low LODs for detecting 3-NT biomarker through "turn-off" luminescence quenching effects and HA biomarker through "turn-on" luminescence enhancement effects. Furthermore, such developed sensor was employed to quantify 3-NT biomarker in serum samples and HA biomarker in urine samples withsatisfactory results. In addition, the possible sensing mechanisms of NiMOF towards HA and 3-NT were also proposed. This work indicates the great potentials of MOFs-based biomarkers chemosensors.