AI Article Synopsis
- The diagnosis of classic Hodgkin lymphoma (CHL) is currently based on tissue analysis through morphology and immunohistochemistry.
- The article highlights specific diagnostic challenges faced in clinical settings, including unusual morphologic variants and atypical antigen expression in HRS cells.
- It also explores conditions that can resemble HRS cells, complicating the diagnosis by including both lymphomatous and non-lymphomatous examples.
Article Abstract
The diagnosis of classic Hodgkin lymphoma (CHL) in clinical practice remains reliant on tissue morphological and immunohistochemical evaluation. In this article, we illustrate specific scenarios that we have encountered in our clinical practice pertaining to diagnostic challenges in CHL. We begin with select presentations of morphologic variants of CHL and then discuss certain immunophenotypic deviations from what is deemed "normal patterns" of antigen expression by HRS cells. Lastly, we discuss mimickers of HRS cells, in lymphomatous and non-lymphomatous conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.humpath.2024.105678 | DOI Listing |
Publication Analysis
Top Keywords
classic hodgkin
8
hodgkin lymphoma
8
clinical practice
8
hrs cells
8
lymphoma illustrative
4
illustrative review
4
review select
4
select diagnostic
4
diagnostic limitations
4
limitations immunomorphological
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!