AI Article Synopsis
- Multiple myeloma (MM) is a serious blood cancer with an increasing patient population, and the role of Zinc finger protein 655 (ZNF655) in its progression is not well understood.
- This study examined how decreasing ZNF655 levels affected MM cell traits and tumor growth, using various lab techniques to measure changes in cell behavior.
- The results showed that reducing ZNF655 significantly decreased MM cell growth, halted the cell cycle, and triggered cell death, suggesting that targeting ZNF655 may offer a new way to treat MM through its effects on AKT activation.
Article Abstract
Multiple myeloma (MM) is an incurable hematological malignancy, and the number of MM patients is increasing year by year. Zinc finger protein 655 (ZNF655) has been shown to regulate various biological processes and is implicated in the progression of many diseases. However, the roles of ZNF655 in MM progression remains unclear. In this study, we aimed to explore the effects of ZNF655 on progression by detecting the alteration of the phenotypes and tumorigenesis induced by ZNF655 knockdown in MM. The expression level of ZNF655 in MM was clarified by real-time quantitative polymerase chain reaction assays. Furthermore, loss-of-function assays in vitro and in vivo was investigated the biological functions of ZNF655 in MM. These findings revealed that ZNF655 depletion remarkably inhibited MM cell proliferation, arrested cell cycle, and induced cell apoptosis. Mechanistically, ZNF655 was found to regulate AKT in MM. In conclusion, this study indicated that ZNF655 regulated the progression of MM via AKT activation and downregulation of ZNF655 may be a promising antitumor strategy in MM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbin.12256 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
ZNF655 involved in the progression of multiple myeloma via the activation of AKT.
Cell Biol Int
November 2024
Department of Hematology, Zibo Central Hospital, Zibo, Shandong Province, China.
Article Synopsis
- Multiple myeloma (MM) is a serious blood cancer with an increasing patient population, and the role of Zinc finger protein 655 (ZNF655) in its progression is not well understood.
- This study examined how decreasing ZNF655 levels affected MM cell traits and tumor growth, using various lab techniques to measure changes in cell behavior.
- The results showed that reducing ZNF655 significantly decreased MM cell growth, halted the cell cycle, and triggered cell death, suggesting that targeting ZNF655 may offer a new way to treat MM through its effects on AKT activation.
Methylated DNA Markers in Voided Urine for the Identification of Clinically Significant Prostate Cancer.
Life (Basel)
August 2024
Department of Urology, Mayo Clinic, Rochester, MN 55905, USA.
Introduction: Non-invasive assays are needed to better discriminate patients with prostate cancer (PCa) to avoid over-treatment of indolent disease. We analyzed 14 methylated DNA markers (MDMs) from urine samples of patients with biopsy-proven PCa relative to healthy controls and further studied discrimination of clinically significant PCa (csPCa) from healthy controls and Gleason 6 cancers.
Methods: To evaluate the panel, urine from 24 healthy male volunteers with no clinical suspicion for PCa and 24 men with biopsy-confirmed disease across all Gleason scores was collected.
Structural basis of the Integrator complex assembly and association with transcription factors.
Mol Cell
July 2024
European Molecular Biology Laboratory, EMBL Grenoble, 71 Avenue des Martyrs, 38042 Grenoble, France. Electronic address:
Integrator is a multi-subunit protein complex responsible for premature transcription termination of coding and non-coding RNAs. This is achieved via two enzymatic activities, RNA endonuclease and protein phosphatase, acting on the promoter-proximally paused RNA polymerase Ⅱ (RNAPⅡ). Yet, it remains unclear how Integrator assembly and recruitment are regulated and what the functions of many of its core subunits are.
View Article and Find Full Text PDFIdentification of macrophage-related genes correlated with prognosis and immunotherapy efficacy in non-small cell lung cancer.
Heliyon
March 2024
Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Jiangsu, Nanjing 21000, China.
Background: Malignant tumours, particularly non-small cell lung cancer (NSCLC), pose a significant threat to human health due to their prevalence and lethality. Treatment methods for NSCLC vary greatly among individuals, making it crucial to identify predictive markers. Moreover, during tumour initiation and progression, tumour cells can release signaling molecules to induce polarization of macrophages towards a more tumour friendly M2 phenotype, which can promote tumour growth, metastasis, and drug resistance.
View Article and Find Full Text PDFRetraction: ZNF655 promotes the progression of glioma through transcriptional regulation of AURKA.
Front Oncol
October 2023
[This retracts the article DOI: 10.3389/fonc.2022.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!