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The Protocol for the Multi-Ethnic, multi-centre raNdomised controlled trial of a low-energy Diet for improving functional status in heart failure with Preserved ejection fraction (AMEND Preserved).
BMJ Open
January 2025
Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester LE3 9QP, UK
Introduction: Heart failure with preserved ejection fraction (HFpEF) is characterised by severe exercise intolerance, particularly in those living with obesity. Low-energy meal-replacement plans (MRPs) have shown significant weight loss and potential cardiac remodelling benefits. This pragmatic randomised trial aims to evaluate the efficacy of MRP-directed weight loss on exercise intolerance, symptoms, quality of life and cardiovascular remodelling in a multiethnic cohort with obesity and HFpEF.
View Article and Find Full Text PDFSocial Return on Investment analysis: A Mixed Methods Approach to Assessing the Value of Adult Hospice Services.
Value Health
January 2025
School of Healthcare Sciences, Bangor University, Bangor, Wales. LL57 2DG. Electronic address:
Objectives Hospice services offer invaluable support to individuals facing life-limiting illnesses, however, quantifying their positive impact presents a challenge. As the demand for palliative care rises due to complex illnesses and an aging population, hospices face the need to prove their value. With funding primarily reliant on charitable donations and limited statutory support, they must demonstrate their effectiveness to secure additional resources in a competitive landscape.
View Article and Find Full Text PDFPlasma Alkylresorcinols is an objective biomarker for gluten intake in young children.
J Nutr
January 2025
Department of Clinical Sciences, Lund university, Malmö, Sweden; Department of Pediatrics, Skåne University Hospital, Malmö. Sweden. Electronic address:
Background: Alkylresorcinols are a well-established biomarker for whole grain intake. There is evidence suggesting that total plasma alkylresorcinol concentration may also be used as a biomarker for gluten intake in adults.
Objective: The aim of the study was to evaluate if total alkylresorcinol concentration is a valid biomarker for gluten intake in young children.
Cost-effectiveness of robotic compared with laparoscopic rectal resection. Results from the Spanish prospective national trial ROBOCOSTES.
Surgery
January 2025
Hepato Pancreato Biliary Unit. Hospital del Mar. Pompeu Fabra University, Barcelona, Spain. Electronic address:
Objective: The costs related to robotic surgery are known to be greater than those associated with laparoscopy. However, the potential for better outcomes of the former could lead to a cost-effectiveness advantage. The aim of this study is therefore to highlight the difference in cost-effectiveness between robotic and laparoscopic rectal resection.
View Article and Find Full Text PDFSafety and efficacy of tamoxifen in non-ambulant patients with Duchenne muscular dystrophy: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial (TAMDMD Group B).
Neuromuscul Disord
January 2025
Division of Neuropediatrics and Developmental Medicine, University Children's Hospital Basel (UKBB), University of Basel, Basel, Switzerland. Electronic address:
Most patients with Duchenne muscular dystrophy (DMD) are non-ambulant. Preserving proximal motor function is crucial, rarely studied. Tamoxifen, a selective oestrogen receptor modulator, reduced signs of muscular pathology in a DMD mouse model.
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