Hospital-level care at home (HCaH) is a modern alternative to traditional inpatient hospitalization (TIH) for acutely ill adults which is cost-effective without impacting patient mortality. Additional outcomes comparing HCaH and TIH have been studied including hospital readmission and post-acute care admission. There is convincing evidence that suggests a trend in the reduction of readmissions following acute hospitalization in the home. Additionally, post-acute care admissions have been significantly reduced following HCaH compared to TIH. The concept of a home hospital allows patients to remain home during acute illness and stay at home longer following discharge, thereby avoiding the need for hospital readmission and post-acute care placement. This research is increasingly important to the aging population in the United States that seeks a safe and beneficial alternative to overwhelmed medical facilities.
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http://dx.doi.org/10.1097/NHH.0000000000001304 | DOI Listing |
Alzheimers Dement
December 2024
BioXcel Therapeutics, New Haven, CT, USA.
Background: BXCL501, a sublingual film formulation of dexmedetomidine, a highly selective α2 adrenoceptor agonist, is currently being studied for the acute treatment of agitation associated with dementia.
Method: This was a Phase 1b/2 study assessing efficacy and tolerability of BXCL501 for treatment of acute agitation associated with dementia. Subjects were randomized to active treatment with BXCL501 (30, 40, or 60µg) or placebo.
Alzheimers Dement
December 2024
IPSIBAT (CONICET/National University of Mar del Plata), Mar del Plata, Buenos Aires, Argentina.
Background: In 2020, we developed LABPSI, a cognitive stimulation web lab. Usability analysis in MCI and healthy participants have already been studied, and currently, we performed it with acquired brain injuries (ABI) participants, as they can rehabilitate their cognitive symptoms and prevent the progression to dementia. Usability can be considered the ease of use of a certain product for a specific aim by a particular population.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Tulane University, New Orleans, LA, USA.
Background: Vascular dementia (VaD), the second most common cause of dementia, is characterized by cognitive decline due to reduced cerebral blood flow and blood-brain barrier disruption. Current evidence demonstrates that not only are VaD patients at higher risk of severe COVID-19 illness and mortality, but also that pre-existing cognitive dysfunction/dementia is associated with increased COVID-19 incidence. Conversely, SARS-CoV-2 infection alone worsens dementia-related mild cognitive impairment (MCI) and increases risk of cognitive decline, supported by similar fMRI findings demonstrating hypoperfusion.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of New South Wales, Sydney, NSW, Australia.
Background: One in four persons living with dementia are admitted to hospital, presenting challenges to them, their carers and staff. Despite global evidence demonstrating the clinical and cost-effectiveness of person-centered care (PCC), it is not yet business as usual across healthcare settings. We used multi-level stakeholder input to implement Kitwood's PCC model into a sub-acute setting.
View Article and Find Full Text PDFBackground: Hospitalized older adults, especially those with Alzheimer's Disease and Related Dementias (PwD), are at high risk for delirium and distressing behaviors. Using physical restraints leads to functional decline and increased mortality. Our project aims to reduce restraint use by implementing a 4Ms approach for enhanced delirium management.
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