Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Adaptive laboratory evolution is an innovative approach utilized by researchers to enhance the characteristics of microorganisms in the field of biology. With the advancement of this technology, it is now being extended to non-model strains. Yarrowia lipolytica, an oleaginous yeast with significant industrial potential, stands out among the non-conventional fungi. However, the activity of Yarrowia lipolytica is frequently affected by specific substances and environmental factors, necessitating the development of techniques to address these challenges. This manuscript provides an overview of adaptive laboratory evolution experiments conducted on Yarrowia lipolytica, and categorizes the contents into two aspects including improving lignocellulose utilization and enhancing the production in Yarrowia lipolytica. Additionally, we selected several representative examples to illustrate how adaptive laboratory evolution can be combined with other techniques to elucidate the potential mechanisms underlying strain evolution. Lastly, we anticipate a promising future for adaptive laboratory evolution technology and Yarrowia lipolytica in tandem.
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Source |
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http://dx.doi.org/10.1016/j.biortech.2023.129893 | DOI Listing |
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