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Application of adaptive laboratory evolution for Yarrowia lipolytica: A comprehensive review. | LitMetric

Application of adaptive laboratory evolution for Yarrowia lipolytica: A comprehensive review.

Bioresour Technol

School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, 2 Xuelin Road, Qixia District, Nanjing 210023, People's Republic of China. Electronic address:

Published: October 2023

AI Article Synopsis

  • Adaptive laboratory evolution is a method that researchers use to improve the traits of microorganisms, and it's now being applied to non-model strains like Yarrowia lipolytica, which has industrial applications.
  • This approach addresses challenges posed by specific substances and environmental factors that can negatively impact Yarrowia lipolytica's activity.
  • The manuscript summarizes experiments focusing on enhancing lignocellulose utilization and production in Yarrowia lipolytica, and discusses how adaptive laboratory evolution can be paired with other techniques to better understand how these strains evolve.

Article Abstract

Adaptive laboratory evolution is an innovative approach utilized by researchers to enhance the characteristics of microorganisms in the field of biology. With the advancement of this technology, it is now being extended to non-model strains. Yarrowia lipolytica, an oleaginous yeast with significant industrial potential, stands out among the non-conventional fungi. However, the activity of Yarrowia lipolytica is frequently affected by specific substances and environmental factors, necessitating the development of techniques to address these challenges. This manuscript provides an overview of adaptive laboratory evolution experiments conducted on Yarrowia lipolytica, and categorizes the contents into two aspects including improving lignocellulose utilization and enhancing the production in Yarrowia lipolytica. Additionally, we selected several representative examples to illustrate how adaptive laboratory evolution can be combined with other techniques to elucidate the potential mechanisms underlying strain evolution. Lastly, we anticipate a promising future for adaptive laboratory evolution technology and Yarrowia lipolytica in tandem.

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Source
http://dx.doi.org/10.1016/j.biortech.2023.129893DOI Listing

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