Prognosis of patients with multiple sclerosis associated with uveitis.

Mult Scler Relat Disord

Department of Neurology Pitié-Salpêtrière Hospital, Sorbonne University, APHP-6, 47-83 Boulevard de l'hôpital, Paris, France. Electronic address:

Published: October 2023

Background: Uveitis may be associated with multiple sclerosis (MS) in 1% of cases. Prognosis of this association remains unknown.

Methods: We conducted a retrospective analysis in a cohort of 41 patients with MS (34 relapsing-remitting MS, and 7 secondary progressive MS) matched with 123 controls (MS without uveitis) followed in Department of Neurology, Pitié Salpêtrière Hospital, Paris.

Results: Mean follow-up was 10.1 years (1.0-29.2). Disability accumulation measured as time to reach EDSS 3 was faster in patients with uveitis compared to the control group (p = 0.003) during follow-up.

Conclusions: Our results suggest that uveitis may be associated with a worse MS prognosis.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msard.2023.105095DOI Listing

Publication Analysis

Top Keywords

multiple sclerosis
8
uveitis associated
8
uveitis
5
prognosis patients
4
patients multiple
4
sclerosis associated
4
associated uveitis
4
uveitis background
4
background uveitis
4
associated multiple
4

Similar Publications

Importance: The prevalence of pharmacies owned by integrated insurers and pharmacy benefit managers (PBMs), or insurer-PBMs, is of growing regulatory concern. However, little is known about the role of these pharmacies in Medicare, in which pharmacy network protections may influence market dynamics.

Objective: To evaluate the prevalence of insurer-PBM-owned pharmacies and the extent to which insurer-PBMs steer patients to pharmacies they own in Medicare.

View Article and Find Full Text PDF

Background: Epstein-Barr virus (EBV) is implicated as a necessary factor in the development of multiple sclerosis (MS) and may also be a driver of disease activity. Although it is not clear whether ongoing viral replication is the driver for MS pathology, MS researchers have considered the prospect of using drugs with potential efficacy against EBV in the treatment of MS. We have undertaken scientific and lived experience expert panel reviews to shortlist existing licensed therapies that could be used in later-stage clinical trials in MS.

View Article and Find Full Text PDF

Background: Hyperreflective retinal foci (HRF) visualized by optical coherence tomography (OCT) potentially represent clusters of microglia. We compared HRF frequencies and their association with retinal neurodegeneration between people with clinically isolated syndrome (pwCIS), multiple sclerosis (pwMS), aquaporin 4-IgG positive neuromyelitis optica spectrum disorder (pwNMOSD), and healthy controls (HC)-as well as between eyes with (ONeyes) and without a history of optic neuritis (ONeyes).

Methods: Cross-sectional data of pwCIS, pwMS, and pwNMOSD with previous ON and HC were acquired at Charité-Universitätsmedizin Berlin.

View Article and Find Full Text PDF

Neuropathological contributions to grey matter atrophy and white matter hyperintensities in amnestic dementia.

Alzheimers Res Ther

January 2025

Laboratory for Clinical Neuroscience, Center for Biomedical Technology, Universidad Politécnica de Madrid, IdISSC, Crta M40, km38, Madrid, 28223, Spain.

Background: Dementia patients commonly present multiple neuropathologies, worsening cognitive function, yet structural neuroimaging signatures of dementia have not been positioned in the context of combined pathology. In this study, we implemented an MRI voxel-based approach to explore combined and independent effects of dementia pathologies on grey and white matter structural changes.

Methods: In 91 amnestic dementia patients with post-mortem brain donation, grey matter density and white matter hyperintensity (WMH) burdens were obtained from pre-mortem MRI and analyzed in relation to Alzheimer's, vascular, Lewy body, TDP-43, and hippocampal sclerosis (HS) pathologies.

View Article and Find Full Text PDF

Introduction: Upper limb (UL) impairment is common in people with multiple sclerosis (pwMS), and functional recovery of the UL is a key rehabilitation goal. Technology-based approaches, like virtual reality (VR), are increasingly promising. While most VR environments are task-oriented, our clinical approach integrates neuroproprioceptive 'facilitation and inhibition' (NFI) principles.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!