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Higher intraoperative blood pressure does not reduce acute kidney injury in noncardiac surgery: what do the results of the POISE-3 trial tell us? | LitMetric
Department of Critical Care, Royal Surrey Hospital Foundation Trust, Guildford, Surrey, UK; School of Medicine, Kate Granger Building, University of Surrey, Guildford, Surrey, UK.
Published: October 2024
AI Article Synopsis
* The POISE-3 randomized controlled trial specifically examined this issue for noncardiac major surgeries, where attempts to raise intraoperative MAP did not lead to reduced rates of postoperative AKI.
* The commentary evaluates both the strengths and limitations of the POISE-3 trial findings and discusses their implications for clinical practice regarding managing blood pressure during surgery.
Article Abstract
Hypotension is a common cause of acute kidney injury (AKI), with strong associations between the duration and magnitude of hypotension seen across a range of situations including major surgery. However, it is less clear whether targeting higher intraoperative MAP results in lower rates of AKI. In a prespecified analysis of the Perioperative Ischemic Evaluation-3 (POISE-3) randomized controlled trial, this question is addressed for noncardiac major surgery. Despite an increase in cessation of antihypertensive medications and higher intraoperative mean arterial blood pressure in the intervention arm, no differences were seen in the rates of postoperative AKI. This commentary discusses the strengths and weaknesses of the trial, as well as providing some interpretation of results and their relevance to clinical practice.
