AI Article Synopsis
- The intestinal epithelium is a constantly renewing tissue, essential for gut health, and its continuous cell turnover is vital for preventing issues like colorectal cancer.
- The review details the cell types in the epithelium and the molecular processes controlling their functioning, linking these to cancer development and progression.
- The second part covers current cancer treatments, ongoing clinical trials, their side effects, and future therapeutic possibilities for colorectal cancer.
Article Abstract
The intestinal epithelium, a rapidly renewing tissue, is characterized by a continuous cell turnover that occurs through a well-coordinated process of cell proliferation and differentiation. This dynamic is crucial for the long-term function of the gastrointestinal tract. Disruption of this process can lead to colorectal carcinoma, a common malignancy worldwide. The first part of the review focuses on the cellular composition of the epithelium and the molecular mechanisms that control its functions, and describes the pathways that lead to epithelial transformation and tumor progression. This forms the basis for understanding the development and progression of advanced colorectal cancer. The second part deals with current therapeutic approaches and presents the latest treatment options, ongoing clinical trials and new drugs. In addition, the biological and medical perspectives of the adverse effects of therapies and models of regeneration of the intestinal epithelium are highlighted and, finally, future treatment options are discussed.
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| http://dx.doi.org/10.1016/j.critrevonc.2024.104544 | DOI Listing |
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