Cardiac arrythmias are common in patients undergoing maintenance hemodialysis. In this issue, Charytan et al. showed that in patients with hyperkalemia (serum potassium concentration 5.10-6.50 mmol/l [5.1-6.5 mEq/l]) on hemodialysis, a dialysate concentration of 3 mEq/l combined with sodium zirconium cyclosilicate on dialysis-free days is associated with a lower frequency of atrial fibrillation compared with a dialysate concentration of 2 mEq/l over 8 weeks. Despite the obvious limitations such as small sample size, short treatment period, and lack of information on longer-term impact on important patient outcomes such as sudden death, this well-conceived pilot study provided impetus for larger prospective trials to test whether this personalized approach reduces major cardiovascular events and mortality.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.kint.2024.10.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive value of creatinine-cystatin C ratio for mortality and technique failure in anuric peritoneal dialysis patients.
Ren Fail
December 2025
National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China.
Objectives: Both serum creatinine and cystatin C serve as dependable markers of renal function and have demonstrated a correlation with clinical outcomes in diverse conditions, particularly through the ratio of creatinine to cystatin C (Cr/CysC). Anuric patients undergoing peritoneal dialysis (PD) depend entirely on the clearance of peritoneal solutes. This research posits that the Cr/CysC ratio may predict all-cause mortality and technique failure in anuric PD patients.
View Article and Find Full Text PDFAnalysis of changes in PCSK9 and TNF-α concentrations in response to physical exercises using virtual reality in patients in the fifth stage of chronic kidney disease undergoing hemodialysis.
BMC Nephrol
January 2025
Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University, Żołnierska 54, Szczecin, 71-210, Poland.
Article Synopsis
- The study investigates the effectiveness of virtual reality (VR) integrated exercise during hemodialysis for patients with stage 5 Chronic Kidney Disease (CKD).
- The research utilized the NefroVR system, allowing patients to perform regular physical training with VR technology.
- Results showed a significant reduction in harmful proteins PCSK9 and TNF-α after three months, indicating potential health benefits from this innovative exercise method.
Bioanalysis of protein-unbound prednisolone in serum using equilibrium dialysis followed by liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
December 2024
Department of Clinical Diagnostics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address:
Introduction: High-dose systemic prednisolone is the cornerstone treatment of many autoimmune- and inflammatory diseases. Since prednisolone shows non-linear protein binding at higher serum concentrations, quantification of the unbound prednisolone concentration is important to understand prednisolone pharmacokinetics. We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay to quantify protein-unbound prednisolone in serum.
View Article and Find Full Text PDFDelafloxacin-Loaded Poly(d,l-lactide--glycolide) Nanoparticles for Topical Ocular Use: Characterization and Antimicrobial Activity.
ACS Omega
December 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11491, Saudi Arabia.
: We developed delafloxacin (Dela)-loaded PLGA nanoparticles (PNPs) for potential ocular application a topical route to treat eye infections caused by Gram-positive and Gram-negative bacteria. : Dela-PNPs were formulated using the emulsification-solvent evaporation method and stabilized using poly(vinyl alcohol) (PVA). Size and morphology were characterized by using dynamic light scattering (DLS) and scanning electron microscopy (SEM).
View Article and Find Full Text PDFAssociation between serum total indoxyl sulfate, intraperitoneal inflammation, and peritoneal dialysis technique failure: a 3-year prospective cohort study.
BMC Nephrol
December 2024
Head Doctor of the Dialysis Medical Center LLC, "Nephrocenter", Dovzhenka 3, Kyiv, 03057, Ukraine.
Background: The impact of protein-bound uremic toxins, specifically indoxyl sulfate (IS) on peritoneal dialysis (PD) complications remains controversial. This study aimed to explore the link between serum total IS (tIS) levels, proinflammatory cytokines in serum and peritoneal dialysis effluent (PDE), and PD technique survival.
Methods: In this prospective cohort study, 84 patients were followed up for three years and analyzed.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!