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Drug Development.
Alzheimers Dement
December 2024
Vanderbilt University Medical Center, Nashville, TN, USA.
Background: We report the case of a 79-year-old woman with Alzheimer's disease who enrolled in a clinical study of lecanemab. After the third, biweekly infusion she suffered a seizure followed by aphasia and progressive encephalopathy. Magnetic resonance imaging revealed multifocal cerebral edema and an increased burden of cerebral microhemorrhages compared to pre-trial imaging.
View Article and Find Full Text PDFMorphological Study on Lenticulostriate Arteries in Patients With Middle Cerebral Artery Stenosis at 7 T MRI.
J Magn Reson Imaging
January 2025
Department of Radiology, the First Medical Center, Chinese PLA General Hospital, Beijing, China.
Background: Middle cerebral artery (MCA) stenosis affects lenticulostriate arteries (LSAs) that supply the basal ganglia. Increased spatial resolution and signal-to-noise ratio of 7 T could facilitate morphological imaging of very-small-diameter LSAs.
Purpose: To evaluate differences in morphological characteristics of LSA among different MCA stenoses.
Prospective Evaluation of Accelerated Brain MRI Using Deep Learning-Based Reconstruction: Simultaneous Application to 2D Spin-Echo and 3D Gradient-Echo Sequences.
Korean J Radiol
January 2025
Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea.
Objective: To prospectively evaluate the effect of accelerated deep learning-based reconstruction (Accel-DL) on improving brain magnetic resonance imaging (MRI) quality and reducing scan time compared to that in conventional MRI.
Materials And Methods: This study included 150 participants (51 male; mean age 57.3 ± 16.
3D CT/MRI fusion image-assisted treatment of lumbar burst fractures with laminar fractures.
BMC Musculoskelet Disord
January 2025
Chinese People's Armed Police Force Special Medical Center, Tianjin, 300300, China.
Background: Lumbar burst fracture combined with lamina fracture is a special type of spinal fracture. Neither CT nor MRI can accurately determine it. The present study aims to investigate the clinical value of 3D CT/MRI fusion imaging in the treatment of lumbar burst fracture complicated with lamina fracture.
View Article and Find Full Text PDFBeating the Size-Dependent Limit with Spin-Lattice Coupling in Nanomagnetism.
J Am Chem Soc
January 2025
Institute of Process Equipment, College of Energy Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, Zhejiang, China.
Further miniaturization of magnetic nanomaterials is intrinsically accompanied by a reduction in spin ordered domains, resulting in size-dependent magnetic behaviors. Consequently, a longstanding roadblock in the advancement of nanodevices based on magnetic nanomaterials is the absence of a method to beat the size-dependent limit in nanomagnetism. Here, we discover and exploit a spin-lattice coupling effect in three-dimensional freestanding magnetic nanoparticles to beat the size-dependent limit for the first time.
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