Magnetism, recognized in ancient Greece and China, is a fundamental physical force influencing numerous domains, including medicine and surgery. Historically, the medical use of magnets dates back over two millennia. As proof, the ancient Sanskrit medical textbook Sushruta Samhita describes the removal of a metallic arrow lodged in the flesh with a magnet. Modern uses span from diagnostic to therapeutic applications, including in paediatric surgery. High-field magnetism, utilized in Magnetic Resonance Imaging and Transcranial Magnetic Stimulation (TMS), shows promise for various medical conditions, including depression and neurodegenerative diseases. Despite controversy surrounding low-field magnetism, its potential remains a topic of interest. One of the applications in paediatric surgery that has been evaluated in a randomized controlled trial is magnetic acupuncture for supplementary treatment of postoperative pain. As most paediatric surgeons are well aware, the use of magnets also poses risks, particularly in children, where ingested magnets can cause severe gastrointestinal complications. Regulations have tightened in response to increasing cases of magnet ingestion-related injuries but more needs to be done to avoid injury. Currently, magnets play crucial roles in a variety of medical applications, including magnetic cell sorting and therapeutic devices. Notably, magnetic compression anastomosis, which uses magnets to facilitate luminal tissue joining, have seen significant advancements. Innovations include devices for oesophageal atresia repair, with recent studies showing promising results in animal models and early clinical trials. Future research should focus on optimizing magnetic devices, expanding their applications, and ensuring safety. The continued exploration of magnetism's effects on living tissues and the development of new magnetic technologies could revolutionize medical and surgical practices, particularly in paediatric care.
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http://dx.doi.org/10.1016/j.jpedsurg.2024.162042 | DOI Listing |
J Am Coll Cardiol
December 2024
Division of Cardiology, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Background: There are no contemporary reports that highlight the national outcomes for children with congenital heart disease (CHD) undergoing ventricular assist device (VAD) implantation.
Objectives: This study sought to evaluate differences in VAD outcomes for children with CHD to those with non-CHD as well as those with univentricular CHD to those with biventricular CHD.
Methods: Data for CHD and non-CHD patients from the multicenter ACTION (Advanced Cardiac Therapies Improving Outcomes Network) undergoing VAD implantation from April 2018 to February 2023 were included.
J Am Coll Cardiol
December 2024
Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
Vaccines (Basel)
November 2024
Pediatric Clinic, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Respiratory syncytial virus (RSV) is a leading cause of respiratory infections, particularly affecting young infants, older adults, and individuals with comorbidities. : This document, developed as a consensus by an international group of experts affiliated with the World Association of Infectious Diseases and Immunological Disorders (WAidid), focuses on recent advancements in RSV prevention, highlighting the introduction of monoclonal antibodies (mAbs) and vaccines. : Historically, RSV treatment options were limited to supportive care and the monoclonal antibody palivizumab, which required multiple doses.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of General Surgery, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China.
Background/objectives: Colorectal cancer (CRC) is characterized by a high rate of both incidence and mortality, and its treatment outcomes are often affected by recurrence and drug resistance. Ferroptosis, an iron-dependent programmed cell death mechanism triggered by lipid peroxidation, has recently gained attention as a potential therapeutic target. Graphene oxide (GO), known for its oxygen-containing functional groups, biocompatibility, and potential for functionalization, holds promise in cancer treatment.
View Article and Find Full Text PDFPharmaceutics
December 2024
Medical Oncology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.
Osteosarcoma is a rare disease, but it is the most frequent malignant bone tumor. Primary treatment consists of preoperative MAP (methotrexate (MTX), doxorubicin and cisplatin) chemotherapy followed by surgery and adjuvant chemotherapy. Pathological response to preoperative chemotherapy is one of the most important prognostic factors, but molecular biomarkers are lacking.
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