Objectives: Several studies have evaluated the prognostic significance of Perineural Invasion (IPN) in laryngeal cancer; however, the results are non-conclusive. Therefore, we conducted a meta-analysis aiming to identify the prognostic value of IPN in laryngeal cancer.
Methods: A literature review was performed, searching MedLine via PubMed, Scielo, Lilacs, Cochrane and Websco. RevMan 5.4 was used for the statistical analysis.
Results: A total of 19 laryngeal cancer studies were included. The results indicate that IPN in laryngeal cancer shows 2-year survival with RR 0.71 (0.59‒0.86); disease-free survival RR 0.51 (0.14-1.95); and locoregional recurrence RR 1.71 (1.25-2.35).
Conclusion: IPN is a negative prognostic factor in laryngeal cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565387 | PMC |
| http://dx.doi.org/10.1016/j.bjorl.2024.101519 | DOI Listing |
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