AI Article Synopsis
- Tissue phantoms are essential for validating biomedical imaging techniques, especially in optical imaging like optical coherence tomography.
- The study focused on developing eye-mimicking phantoms using various materials and incorporating microfluidic channels to simulate blood vessels.
- A 3D model was created to represent the anatomy of the eye, particularly the retina and contact lens, which could lead to advancements in combined imaging technologies.
Article Abstract
Tissue phantoms play an important role in validating biomedical imaging techniques. For optical imaging systems such as optical coherence tomography, creating layers of phantoms with different refractive indices is important. This paper explored various phantom materials to create eye-mimicking phantoms. The phantom also included microfluidic channels to mimic vasculature. To verify the optical properties of the created phantom, the transmission and reflection spectroscopy was performed using a photoluminescent spectrometer studying the complete visible and near infrared spectrum. We created a 3D model to house multiple layers that mimicked the retina at one end and the contact lens at the other, representing the anterior segment of the eye. A realistic retinal layer-mimicking, which, among other things, may pave the way for new combined imaging modalities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/03913988241289847 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration.
J Neuroinflammation
January 2025
Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Background: The retinal degenerative diseases retinitis pigmentosa (RP) and atrophic age- related macular degeneration (AMD) are characterized by vision loss from photoreceptor (PR) degeneration. Unfortunately, current treatments for these diseases are limited at best. Genetic and other preclinical evidence suggest a relationship between retinal degeneration and inflammation.
View Article and Find Full Text PDFAssessment of retinal pigment epithelium tears in eyes with submacular hemorrhage secondary to age-related macular degeneration.
Sci Rep
January 2025
Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
To assess retinal pigment epithelium (RPE) tears in eyes which underwent pars plana vitrectomy (PPV) for submacular hemorrhage (SMH) secondary to age-related macular degeneration and to investigate the prognostic factors of visual outcomes. This study was a retrospective, observational case series that included 24 eyes of 24 patients who underwent PPV with subretinal tissue plasminogen activator and air for SMH. RPE tears were investigated using spectral-domain or swept-source optical coherence tomography images with raster scan, combined confocal scanning laser ophthalmoscope near-infrared images and color fundus photographs.
View Article and Find Full Text PDFOCT-based diagnosis of glaucoma and glaucoma stages using explainable machine learning.
Sci Rep
January 2025
School of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia.
Glaucoma poses a growing health challenge projected to escalate in the coming decades. However, current automated diagnostic approaches on Glaucoma diagnosis solely rely on black-box deep learning models, lacking explainability and trustworthiness. To address the issue, this study uses optical coherence tomography (OCT) images to develop an explainable artificial intelligence (XAI) tool for diagnosing and staging glaucoma, with a focus on its clinical applicability.
View Article and Find Full Text PDFUnusual Coats-like response in occlusive retinal periphlebitis.
BMJ Case Rep
January 2025
Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Coats-like response refers to a condition where abnormal telangiectatic retinal vessels and aneurysms associated with subretinal exudation are seen in the setting of other ocular or systemic diseases. So far, it has been described with various ocular disorders like retinitis pigmentosa, chronic ischemic branch retinal vein obstruction and pars planitis. A man in his 30s presented with a 1-month history of diminution of vision in the left eye.
View Article and Find Full Text PDFFemtosecond Laser-Assisted Pterygium Surgery Using a Customized Algorithm for Trapezoidal Conjunctival Grafts.
Cornea
January 2025
Tissue Engineering & Cell Therapy Group, Singapore Eye Research Institute, Singapore.
Purpose: Conjunctival autografts (CAGs) are the gold standard treatment after pterygium resection, but it is challenging to achieve consistently thin Tenon-free CAGs with manual dissection. We herein report the reproducibility and clinical outcomes of a novel algorithm to produce customizable trapezoidal CAGs using femtosecond laser (femtosecond lasers)-assisted pterygium surgery.
Methods: We first tested this algorithm in 4 pig eyes to show reproducibility.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!