AI Article Synopsis
- Residual microcalcifications on mammograms after neoadjuvant chemotherapy (NACT) complicate surgical decisions in breast cancer treatment.
- A study assessed the link between these microcalcifications and pathological complete response (pCR), finding no significant relationship (p = 0.763).
- Additionally, the impact of residual microcalcifications on recurrence and overall survival was determined to be non-significant, suggesting their predictive and prognostic value is still uncertain and should be evaluated on a case-by-case basis.
Article Abstract
Residual microcalcifications on mammograms after neoadjuvant chemotherapy (NACT) pose a challenge in surgical decision-making. This single-centre retrospective review of all patients who had NACT for breast cancer over five years, evaluated the relationship between pathological complete response and residual microcalcifications, controlling for tumour size, nodal stage, grade, and receptor status, as well as the impact of residual microcalcifications on recurrence and survival. There was no significant association between pathological complete response (pCR) and residual microcalcifications (p = 0.763). We computed hazard ratios (HR) for Time to recurrence (TTR) and overall survival (OS) which were both not significant, with HR = 2.599, [0.290, 23.264], p = 0.393 and HR = 1.362 [0.123, 15.062], p = 0.801 respectively. The predictive and prognostic significance of residual microcalcifications remains to be proven. The surgical excision of these lesions should be considered based on individual patient risk.
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| http://dx.doi.org/10.1016/j.ejso.2024.108781 | DOI Listing |
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