New Approaches to the Treatment of Hypercortisolism.

Annu Rev Med

1Oxford Centre for Diabetes, Endocrinology, and Metabolism and National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre, University of Oxford, Churchill Hospital, Oxford, United Kingdom; email:

Published: November 2024

This review explores the evolving landscape of treatments for hypercortisolism, highlighting both established and emerging therapies. Although surgery remains the cornerstone of management, medical therapies play a crucial and expanding role, especially in cases of persistent, recurrent, or severe hypercortisolism. We discuss the effectiveness and limitations of steroidogenesis inhibitors, pituitary-directed drugs, glucocorticoid receptor antagonists, and experimental drugs targeting novel molecular pathways that have been implicated in the pathogenesis of hypercortisolism. Despite advancements, significant unmet needs persist, underscoring the importance of personalized treatment approaches and the development of targeted therapies. Ongoing and future clinical trials are crucial for validating the safety and efficacy of these innovative treatments in Cushing disease management.

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Source
http://dx.doi.org/10.1146/annurev-med-071723-044849DOI Listing

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