Redefining the Gastric Microbes in Promoting Gastric Tumorigenesis: The Rise of the Non-H. pylori Microbiome.

Cancer Discov

State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

Published: November 2024

AI Article Synopsis

  • - Gastric cancer is a major health issue in China, with higher rates than in Western countries, largely due to Helicobacter pylori infections.
  • - New research is revealing the role of non-H. pylori bacteria in the stomach, changing how we think about the causes of gastric cancer.
  • - These findings are expected to influence future approaches to screening and preventing gastric cancer in at-risk populations.

Article Abstract

Gastric cancer remains one of the top cancers in China compared with Western countries, mainly attributed to the high rates of Helicobacter pylori infection. However, recent discoveries on the non-H. pylori gastric microbiome have led to a paradigm shift in our understanding of microbial risk factors driving gastric cancer, which will impact future screening and prevention strategies.

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http://dx.doi.org/10.1158/2159-8290.CD-24-0835DOI Listing

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