Gastric cancer remains one of the top cancers in China compared with Western countries, mainly attributed to the high rates of Helicobacter pylori infection. However, recent discoveries on the non-H. pylori gastric microbiome have led to a paradigm shift in our understanding of microbial risk factors driving gastric cancer, which will impact future screening and prevention strategies.
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http://dx.doi.org/10.1158/2159-8290.CD-24-0835 | DOI Listing |
Int J Mol Sci
December 2024
Host Microbiome Interaction, Clinical Pharmacology and Therapeutics, Institute of Pharmaceutical Science, King's College London, London SE1 9NH, UK.
Epidemiological and eradication trial evidence indicates that , a major causative factor in peptic ulcer and gastric cancer, is a driver of the hypokinesia of Parkinson's disease (PD). Psychological (cognitive impairment, depression and anxiety) and gastrointestinal (peptic ulceration and constipation) PD features can precede the symptomatic onset of motor features by decades. We hypothesise that the non- (NHPH), which have farm, companion and wild animals as their main hosts, can have a role in PD aetiopathogenesis.
View Article and Find Full Text PDFIntern Med
November 2024
Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan.
Helicobacter pylori eradication is effective for the regression of gastric hyperplastic polyps (GHPs). We report a case which demonstrated an enlargement of GHPs after H. pylori eradication.
View Article and Find Full Text PDFCancer Discov
November 2024
State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Institute of Digestive Disease, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
World J Gastrointest Oncol
September 2024
Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 311122, Zhejiang Province, China.
BMJ Open Gastroenterol
August 2024
IQVIA Germany, Frankfurt, Hessen, Germany.
Background: () is a gram-negative gastrointestinal pathogen that colonises the human stomach and is considered a major risk factor for gastric cancer and mucosa-associated lymphoid tissue lymphoma. Furthermore, is a potential trigger of a wide spectrum of extragastric cancer entities, extraintestinal chronic inflammatory processes and autoimmune diseases. In the present study, we evaluated the association between infection and its eradication with the development of subsequent gastrointestinal and non-gastrointestinal cancer.
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