AI Article Synopsis
- Annual low-dose CT scans can detect early-stage lung tumors in smokers and lower cancer death rates by 20%, but many eligible patients don’t get screened.
- Mazzone and his team have developed a blood test that analyzes cfDNA to identify individuals who might benefit from further CT imaging.
- This pre-screening approach aims to improve screening rates and focus resources on those at higher risk for lung cancer.
Article Abstract
Annual low-dose CT screening of individuals with a smoking history identifies early curable lung tumors and reduces cancer mortality by 20%, yet only a minority of eligible patients undergo such monitoring. Mazzone and colleagues apply a blood-based cfDNA fragmentomic assay as a high-sensitivity/low-specificity pre-screen to help stratify individuals who may benefit most from more definitive low-dose CT imaging. See related article by Mazzone et al., p. 2224.
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| http://dx.doi.org/10.1158/2159-8290.CD-24-1195 | DOI Listing |
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