In order to make more rational use of , a systematic separation from the roots of was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (), together with four known analogues (). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound also significantly affected the levels of inflammatory cytokines.

Download full-text PDF

Source
http://dx.doi.org/10.1080/10286020.2024.2421918DOI Listing

Publication Analysis

Top Keywords

rare prenylated
8
prenylated isoflavone-quinone
8
isoflavone-quinone roots
4
roots order
4
order rational
4
rational systematic
4
systematic separation
4
separation roots
4
roots performed
4
performed current
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!