AI Article Synopsis

  • Type 2 diabetes mellitus (T2DM) leads to smaller pial vessels and lower blood flow velocity before and after a stroke, contributing to poor recovery outcomes.
  • After a stroke, T2DM mice showed persistent deficits in blood flow and increased leukocyte adhesion to blood vessel walls, highlighting chronic inflammation's role in complicating recovery.
  • The study used two-photon microscopy to analyze blood flow dynamics, vessel remodeling, and inflammation in the brain, suggesting that T2DM-induced changes worsen stroke effects.

Article Abstract

Type 2 diabetes mellitus (T2DM) is associated with impaired leptomeningeal collateral compensation and poor stroke outcome. Neutrophils tethering and rolling on endothelium after stroke can also independently reduce flow velocity. However, the chronology and topological changes in collateral circulation in T2DM is not yet defined. Here, we describe the spatial and temporal blood flow dynamics and vessel remodeling in pial arteries and veins and leukocyte-endothelial adhesion following middle cerebral artery (MCA) stroke using two-photon microscopy in awake control and T2DM mice. Relative to control mice prior to stroke, T2DM mice already exhibited smaller pial vessels with reduced flow velocity. Following stroke, T2DM mice displayed persistently reduced blood flow in pial arteries and veins, resulting in a poor recovery of downstream penetrating arterial flow and a sustained deficit in microvascular flow. There was also persistent increase of leukocyte adhesion to the endothelium of veins, coincided with elevated neutrophils infiltration into brain parenchyma in T2DM mice compared to control mice after stroke. Our data suggest that T2DM-induced increase in chronic inflammation may contribute to the remodeling of leptomeningeal collateral circulation and the observed hemodynamics deficiency that potentiates poor stroke outcome.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526934PMC
http://dx.doi.org/10.1101/2024.10.23.619748DOI Listing

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