AI Article Synopsis
- Brain radiation helps control tumors in the brain but can cause cognitive impairments due to indirect damage from free radicals.
- This damage leads to long-term cognitive issues, known as late neurotoxicity, which is a direct result of radiation therapy.
- The review discusses how certain drugs and antioxidants, like ascorbate, may protect against these side effects, with existing research suggesting these methods are effective and cost-efficient.
Article Abstract
Brain radiation is a crucial tool in neuro-oncology for enhancing local tumor control, but it can lead to mild-to-profound and progressive impairments in cognitive function. Radiation-induced brain injury is a significant adverse effect of radiotherapy for cranioencephalic tumors, primarily caused by indirect cellular damage through the formation of free radicals. This results in late neurotoxicity manifesting as cognitive impairment due to free radical production. The aim of this review is to highlight the role of different substances, such as drugs used in the clinical setting and antioxidants such as ascorbate, in reducing the neurotoxicity associated with radiation-induced brain injury. Currently, there is mainly preclinical and clinical evidence supporting the benefit of these interventions, representing a cost-effective and straightforward neuroprotective strategy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503407 | PMC |
| http://dx.doi.org/10.3390/neurosci5040034 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!