Background: This meta-analysis aimed to investigate the effects of traditional Chinese exercises on stroke and explore the dose-response relationship between the type of exercise and exercise duration with respect to physical and mental health.
Methods: We searched PubMed, Web of Science, EBSCO, China National Knowledge Infrastructure (CNKI), Wan Fang Database, and China Science and Technology Journal Database to identify published randomized controlled trials (RCTs) related to stroke patients and traditional Chinese exercise that met the evaluation criteria, from the inception of the database until September 2022. After assessing the quality of the literature, we used RevMan5.4 for data analysis.
Results: A total of 27 RCTs were included. The results of the meta-analysis revealed that motor function [MD = 4.79, 95% CI: (4.14, 5.43), < 0.001], balance function [MD = 5.25, 95% CI: (3.93, 6.56), < 0.001], and mental health [MD = -2.42, 95% CI: (-3.92 to -0.92), = 0.002] were significantly better in the experimental group than in the control group.
Conclusion: Traditional Chinese exercises have a positive effect on the physical and mental health of stroke patients, with the most significant benefit observed in balance function. While traditional Chinese exercises improve exercise capacity and mental health in stroke patients, these improvements are not directly correlated with longer practice time, and there appear to be certain limitations regarding duration.
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http://dx.doi.org/10.3389/fneur.2024.1455679 | DOI Listing |
J Med Chem
March 2025
State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine; Shanghai Frontiers Science Center of TCM Chemical Biology; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
The anticancer agent irinotecan often induces severe delayed-onset diarrhea, inhibiting human carboxylesterase 2A (hCES2A) can significantly alleviate irinotecan-triggered gut toxicity (ITGT). This work presents an efficient workflow for design and developing novel efficacious hCES2A inhibitors. A well-training machine learning model identified as a lead compound, while compound was developed as a novel time-dependent hCES2A inhibitor (IC = 0.
View Article and Find Full Text PDFACS Appl Mater Interfaces
March 2025
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
High-performance radiation-resistant lubricating materials (RRLMs) with nanostructures hold great promise for enhancing the irradiation tolerance because of their sinking effect of boundaries on defects. Despite recent advances, challenges remain in finding a nanostructure that exhibits both superior irradiation tolerance and excellent lubricant properties. Unlike traditional nanostructured composite materials that required complex predesign, herein, a MoS nanocrystals (NCs)/amorphous dual phase in subirradiation saturation (SIS) state was spontaneously formed during irradiation, exhibiting high irradiation resistance under the synergistic effect of "defect traps" by interfaces and edge dislocation.
View Article and Find Full Text PDFClin Rheumatol
March 2025
Laboratory of Human Anatomy, School of Basic Medicine Anatomy , Southwest Medical University, Xianglin Road, Longmatan District, Luzhou City, Sichuan Province, China.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by complex immune interactions. Elucidating the causal relationships between blood cell perturbations, immune cell subsets, and RA can provide valuable insights into its pathogenesis.
Methods: This study employed bidirectional two-sample Mendelian Randomization (MR) to explore the causal effects of blood cell perturbations on RA risk, with a focus on immune cell mediation.
Dig Dis Sci
March 2025
Coloproctology Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai, 200030, China.
Discov Oncol
March 2025
Department of Anorectal Surgery, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, 58 Lushan Rd., Yuelu District, Changsha, 410006, Hunan, People's Republic of China.
Background: Asian cancer patients have become the highest morbidity and mortality group, and gastrointestinal tumors account for the majority of them, so it is urgent to find effective targets. Therefore, ferroptosis-related lncRNAs models were established to predict the prognosis and clinical immune characteristics of GI cancer.
Methods: RNA sequencing and clinical data were collected from the TCGA database (LIHC, STAD, ESCA, PAAD, COAD, CHOL, and READ) of patients with gastrointestinal cancer in Asia.
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