Spaceflight Associated Neuro-ocular Syndrome (SANS) is a series of findings found in astronauts who have experienced long-duration spaceflight. It is characterized by neuro-ocular changes that may irreversibly alter vision and increase the risk for the development of terrestrial eye and brain disorders. Theories regarding its etiology and countermeasures to combat the findings seen continue to evolve. There is currently no direct treatment for SANS. Traditional Chinese Medicine (TCM) modalities have been used to treat eye and brain disorders on Earth that are pathogenically similar to SANS, therefore, TCM may be able to target corresponding pathology in astronauts, prevent and mitigate SANS findings, and decrease the risk for future development of disorders. This paper intends to discuss pathological similarities between SANS and terrestrial eye and brain disorders and how TCM has been used to treat those disorders.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525009 | PMC |
http://dx.doi.org/10.3389/fopht.2024.1487992 | DOI Listing |
Ann Med
December 2025
Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Purpose: To evaluate levels of 3 tear-soluble neuropeptides in dry eye patients and to identify the correlations with clinical signs and symptoms.
Methods: A total of 16 dry eye patients and 12 healthy volunteers were enrolled. Dry eye disease (DED) diagnosis was based on the 2017 Report of the Tear Film & Ocular Surface Society International Dry Eye Workshop (TFOS DEWS II).
Endocr Oncol
January 2024
Department of Oncology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.
Summary: Craniopharyngiomas (CPs) are rare brain epithelial tumours arising in the suprasellar region, infiltrating adjacent areas causing visual loss, panhypopituitarism, cognitive deficits and morbid obesity. Papillary CPs (PCPs) harbour in 94% BRAF mutation cases. Two patients with PCP and BRAF V600E mutations but with different tumour status were treated with BRAF and MEK inhibitors.
View Article and Find Full Text PDFAlzheimers Dement (Amst)
January 2025
Introduction: We explored associations between measurements of the ocular choroid microvasculature and Alzheimer's disease (AD) risk.
Methods: We measured the choroidal vasculature appearing in optical coherence tomography (OCT) scans of 69 healthy, mid-life individuals in the PREVENT Dementia cohort. The cohort was prospectively split into low-, medium-, and high-risk groups based on the presence of known risk factors (apolipoprotein E [] ε4 genotype and family history of dementia [FH]).
Graefes Arch Clin Exp Ophthalmol
January 2025
Institute of Brain Diseases and Cognition, School of Medicine, Xiamen University, Xiamen, 361102, Fujian, China.
High altitude (HA) exposure induces impairments in visual function. This study was designed to dynamically observe visual function after returning to lowland and elucidate the underlying mechanism by examining the structure and function of retina and visual pathway. Twenty-three subjects were recruited before (Test 1), and one week (Test 2) and three months (Test 3) after their return from HA (4300 m) where they resided for 30 days.
View Article and Find Full Text PDFNeural Regen Res
January 2025
Molecular Neuropharmacology Laboratory and Eye-Brain Research Center, State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of disease-modifying treatments. The glymphatic system, a recently identified perivascular fluid transport network, is crucial for clearing neurotoxic proteins. This review aims to synthesize current knowledge on the role of the glymphatic system in α-synuclein clearance and its implications for the pathology of Parkinson's disease while emphasizing potential therapeutic strategies and areas for future research.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!