A young adult male presented as a case of meningitis in the background of a ventriculoperitoneal shunt in situ, uncontrolled type 1 diabetes and a history of treated abdominal tuberculosis. The patient presented with complaints of high-grade fever, non-projectile vomiting, headache and drowsiness. He was eventually diagnosed as a case of fungal meningitis. The patient's cerebrospinal fluid analysis (CSF) analysis revealed budding yeast cells and the culture revealed Apiotrichum mycotoxinivorans. This is a yeast-like fungus that is known to cause opportunistic infections in an immunocompromised host. This is a rare cause of fungal meningitis and very few cases have been reported worldwide. This is the first case of Apiotrichum mycotoxinivorans-associated meningitis reported from India.
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http://dx.doi.org/10.7759/cureus.70573 | DOI Listing |
Appl Environ Microbiol
December 2024
Department of Life Sciences, Chalmers University of Technology, Gothenburg, Västra Götaland County, Sweden.
Unlabelled: Bioprospecting can uncover new yeast strains and species with interesting ecological characteristics and valuable biotechnological traits, such as the capacity to convert different carbon sources from industrial side and waste streams into bioproducts. In this study, we conducted untargeted yeast bioprospecting in tropical West Africa, collecting 1,996 isolates and determining their growth in 70 different environments. While the collection contains numerous isolates with the potential to assimilate several cost-effective and sustainable carbon and nitrogen sources, we focused on characterizing the 203 strains capable of growing on lactose, the main carbon source in the abundant side stream cheese whey from dairy industries.
View Article and Find Full Text PDFPol J Microbiol
December 2024
Department of Clinical Laboratory, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Opportunistic infections caused by fungi, particularly those occurring in immunocompromised patients, are considered challenging worldwide. Therefore, a comprehensive understanding of pathogenic fungi is necessary. The present study reports the isolation of a strain of , which is difficult to detect using conventional clinical assays, from the sterile urine samples of a patient with a urinary tract infection.
View Article and Find Full Text PDFCureus
September 2024
Internal Medicine, Max Smart Super Specialty Hospital, New Delhi, IND.
Eur J Clin Microbiol Infect Dis
March 2024
Microbiology Laboratory, Children's Hospital Affiliated to Shandong University, Jinan, 250022, China.
Fungal infections due to Apiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection by Apiotrichum mycotoxinivorans in a girl with B-cell acute lymphoblastic leukemia. This is the first report of the isolation of Apiotrichum mycotoxinivorans from human cerebrospinal fluid.
View Article and Find Full Text PDFEcotoxicol Environ Saf
November 2022
Department of Clinical Laboratory, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Ochratoxin A (OTA) is one of the most common and deleterious mycotoxins found in food and feedstuffs worldwide; however, Apiotrichum mycotoxinivorans can detoxify OTA. Our results show that A. mycotoxinivorans GUM1709 efficiently degraded OTA, but it caused the accumulation of intracellular reactive oxygen species.
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