AI Article Synopsis

  • * He experienced high fever, vomiting, headache, and drowsiness before being diagnosed with fungal meningitis caused by Apiotrichum mycotoxinivorans.
  • * This specific case marks a rare instance of fungal meningitis linked to this particular fungus and is the first reported case in India.

Article Abstract

A young adult male presented as a case of meningitis in the background of a ventriculoperitoneal shunt in situ, uncontrolled type 1 diabetes and a history of treated abdominal tuberculosis. The patient presented with complaints of high-grade fever, non-projectile vomiting, headache and drowsiness. He was eventually diagnosed as a case of fungal meningitis. The patient's cerebrospinal fluid analysis (CSF) analysis revealed budding yeast cells and the culture revealed Apiotrichum mycotoxinivorans. This is a yeast-like fungus that is known to cause opportunistic infections in an immunocompromised host. This is a rare cause of fungal meningitis and very few cases have been reported worldwide. This is the first case of Apiotrichum mycotoxinivorans-associated meningitis reported from India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525039PMC
http://dx.doi.org/10.7759/cureus.70573DOI Listing

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  • * He experienced high fever, vomiting, headache, and drowsiness before being diagnosed with fungal meningitis caused by Apiotrichum mycotoxinivorans.
  • * This specific case marks a rare instance of fungal meningitis linked to this particular fungus and is the first reported case in India.
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Fungal infections due to Apiotrichum mycotoxinivorans are clinically rare. Here, we report a case of invasive blood and cerebrospinal fluid infection by Apiotrichum mycotoxinivorans in a girl with B-cell acute lymphoblastic leukemia. This is the first report of the isolation of Apiotrichum mycotoxinivorans from human cerebrospinal fluid.

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Ochratoxin A (OTA) is one of the most common and deleterious mycotoxins found in food and feedstuffs worldwide; however, Apiotrichum mycotoxinivorans can detoxify OTA. Our results show that A. mycotoxinivorans GUM1709 efficiently degraded OTA, but it caused the accumulation of intracellular reactive oxygen species.

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