Bongkrekic acid (BA) is a lipotoxin that can cause fatal food poisoning. Severe BA poisoning can rapidly progress from liver and kidney damage to multiple organ failure and is rarely manifested as persistent hypoglycemia and rhabdomyolysis. It has a high mortality rate and poor prognosis. However, clinical data on patients with foodborne BA poisoning are limited. The aim of this study is to summarize the characteristics of patients with BA poisoning, provide reference for early diagnosis and treatment, and improve the survival rate and prognosis of patients with BA poisoning.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526843 | PMC |
| http://dx.doi.org/10.7759/cureus.70625 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Severe bongkrekic acid poisoning caused by eating spoiled Auricularia auricula: a case report.
BMC Complement Med Ther
December 2024
Department of Occupational and Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Background: Bongkrekic acid is a rare mitochondrial toxin produced by the Burkholderia cocovenenans subsp. Bongkrekic acid poisoning has a case fatality rate of more than 50%, and progresses rapidly to multiple organ failure. However, limited clinical information is available regarding this phenomenon.
View Article and Find Full Text PDFGenomic Characterization and Comparative Genomic Analysis of the Foodborne pv. .
Foodborne Pathog Dis
November 2024
Shenzhen Academy of Metrology and Quality Inspection/National Nutrition Food Testing Center (Guangdong), Shenzhen, China.
Article Synopsis
- - This study focuses on a specific foodborne pathogen linked to fatal food poisoning, exploring its ability to produce the dangerous toxin bongkrekic acid (BA) and characterizing its genomic diversity based on 17 strains from Shenzhen City, China.
- - Genome sequencing revealed that most strains had an approximate size of 8 Mb and a GC content around 68%, with significant evolutionary divergences noted in their genomic structures.
- - Key findings show that certain strains possess a complete gene cluster necessary for BA production, while others exhibit gene disruptions or lack this cluster, indicating variations in their BA-producing capability and emphasizing the importance of these genomic features in understanding food poisoning risks.
Unexplained Rhabdomyolysis and Hepatic Renal Dysfunction: A Case of Bongkrekic Acid Poisoning.
Cureus
October 2024
Medicine, Zhejiang Wuxing High School, Huzhou, CHN.
Bongkrekic acid (BA) is a lipotoxin that can cause fatal food poisoning. Severe BA poisoning can rapidly progress from liver and kidney damage to multiple organ failure and is rarely manifested as persistent hypoglycemia and rhabdomyolysis. It has a high mortality rate and poor prognosis.
View Article and Find Full Text PDFANT-Mediated Inhibition of the Permeability Transition Pore Alleviates Palmitate-Induced Mitochondrial Dysfunction and Lipotoxicity.
Biomolecules
September 2024
Department of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.
Hyperlipidemia is a major risk factor for vascular lesions in diabetes mellitus and other metabolic disorders, although its basis remains poorly understood. One of the key pathogenetic events in this condition is mitochondrial dysfunction associated with the opening of the mitochondrial permeability transition (MPT) pore, a drop in the membrane potential, and ROS overproduction. Here, we investigated the effects of bongkrekic acid and carboxyatractyloside, a potent blocker and activator of the MPT pore opening, respectively, acting through direct interaction with the adenine nucleotide translocator, on the progression of mitochondrial dysfunction in mouse primary lung endothelial cells exposed to elevated levels of palmitic acid.
View Article and Find Full Text PDFThe first time devastating food poisoning happened in Taiwan - Bongkrekic acid poisoning.
Taiwan J Obstet Gynecol
September 2024
Toxicology Division, Department of Emergency Medicine, MacKay Memorial Hospital, Taipei 10449, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan; MacKay Junior College of Medicine, Nursing, and Management, Taipei City 11260, Taiwan; Department of Nursing, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan. Electronic address:
Bongkrekic acid (BKA), a rarely happened foodborne toxin by Burkholderia gladioli pathovar cocovenenans (Burkholderia cocovenenans) might leads to devastating life-threatening condition after eating meal contaminated BKA. Unbelievable event from March 19, 2024, to March 24, 2024, there was an outbreak of BAP in a luxury shopping area of eastern Taipei, Taiwan. Most of the victims are young to middle-aged people who made a tour over there and ate the cooked wet rice noodles.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!