A new sulfonyl fluoride reagent 1-bromobut-3-ene-1,3-disulfonyl difluoride (BEDF) was developed. This unique reagent possesses two clickable functionalities to be used for both azide-alkyne cycloaddition click and SuFEx click reactions. This new reagent was applied for the regioselective construction of a class of novel triazolyl vinyl sulfonyl fluorides in which the C-4 position 1-1,2,3-triazoles were functionalized with vinyl sulfonyl fluorides of exclusively -configuration.
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| http://dx.doi.org/10.1021/acs.joc.4c02186 | DOI Listing |
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