Ovarian cancer in children and adolescents: A unique clinical challenge.

Eur J Surg Oncol

Division of Gynaecology and Obstetrics, Department of Gynaecology University Medical Centre Ljubljana, Slajmerjeva 3, 1000, Ljubljana, Slovenia; Medical Faculty, University of Ljubljana, Vrazov Trg 2, 1000, Ljubljana, Slovenia.

Published: October 2024

AI Article Synopsis

  • - Ovarian cancer in children and adolescents is uncommon and requires a specialized approach, involving a team of healthcare providers to address its unique diagnostic and treatment challenges.
  • - Diagnosis often involves imaging tests and tumor markers, while surgical treatments should prioritize fertility preservation whenever possible, along with tailored chemotherapy based on the type of cancer and its stage.
  • - Early detection leads to high survival rates of over 90%, but ongoing follow-up is essential to monitor for recurrence and manage any long-term side effects from treatment.

Article Abstract

Ovarian cancer in children and adolescents is rare, presenting unique diagnostic and management challenges distinct from adult cases. This paper provides a comprehensive overview of this disease, focusing on the importance of a multidisciplinary approach to care. We discuss the common presentation of ovarian malignant masses in young patients, highlighting the role of imaging and tumor markers in diagnosis. The paper delves into the surgical management of these tumors, emphasizing the importance of fertility-sparing techniques whenever possible. We explore the role of adjuvant chemotherapy, considering histological subtypes and disease stage. Furthermore, we address the good prognosis associated with early diagnosis and treatment, with survival rates exceeding 90 % in many cases. Finally, the need for long-term follow-up to monitor for potential recurrence is underscored and the long-term treatment-related effects are addressed. This review aims to guide clinicians in providing optimal care for this unique patient population, emphasizing the importance of balancing oncological control with the preservation of future fertility and quality of life.

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http://dx.doi.org/10.1016/j.ejso.2024.108785DOI Listing

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