Gene expression regulation in hypoxic tumor microenvironments is mediated by O responsive transcription factors (OR-TFs), fine-tuning cancer cell metabolic demand for O according to its availability. Here, we discuss key OR-TFs and emerging artificial intelligence (AI)-based applications suitable for the interrogation of OR-TF relationships specifying cancer cell metabolic adaptations to hypoxia.
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| http://dx.doi.org/10.1016/j.trecan.2024.10.003 | DOI Listing |
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