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Dantrolene inhibition of ryanodine receptor 1 carrying the severe malignant hyperthermia mutation Y522S visualized by cryo-EM.
Structure
December 2024
Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA. Electronic address:
Mutations in the skeletal isoform of the ryanodine receptor 1 (RyR1) pose grave risks during anesthesia or treatment with succinylcholine muscle relaxants. These can trigger a potentially lethal malignant hyperthermia (MH) episode via intracellular calcium increase mainly from RyR1 channel leakage. Dantrolene is the only known treatment option to prevent death.
View Article and Find Full Text PDFThe Synergy of Thermal and Non-Thermal Effects in Hyperthermic Oncology.
Cancers (Basel)
November 2024
Department of Biotechnics, Hungarian University of Agriculture and Life Sciences, 2100 Gödöllő, Hungary.
Background: Modulated electro-hyperthermia (mEHT) is unique due to its combination of thermal and non-thermal effects.
Method: This report summarizes the literature on the effects of mEHT observed in vitro and in vivo.
Results: The thermal and electrical heterogeneity of tissues allows the radiofrequency signal to selectively target malignant tissue.
Diagnostic Challenges in Malignant Hyperthermia and Anesthesia-Induced Rhabdomyolysis: A Case Study.
Am J Case Rep
December 2024
Department of Surgery, Medical University of Sofia, University Hospital "Queen Giovanna - ISUL", Sofia, Bulgaria.
BACKGROUND Malignant hyperthermia (MH) and anesthesia-induced rhabdomyolysis (AIR) are rare, yet life-threatening complications that need prompt therapeutic actions and logistic preparedness for treatment success. Both conditions are triggered by general anesthetics, particularly volatiles and depolarizing muscle relaxants. In comparison with MH, which is an inherited pharmacogenomic disease of calcium channel receptor subpopulation and arises only after trigger exposure, AIR has been described mostly in patients with muscular dystrophies.
View Article and Find Full Text PDFThe Use of Zolpidem in Catatonia: A Case Report.
Cureus
November 2024
Old Age Psychiatry, University Hospital Wishaw, Wishaw, GBR.
Catatonia is a complex neuropsychiatric syndrome characterised by abnormal psychomotor disturbance, which poses a diagnostic and treatment challenge to clinicians. It is a life-threatening condition in its severe form, termed malignant and characterised by hyperthermia and autonomic disturbances. Early recognition and treatment are important in its management.
View Article and Find Full Text PDFMalignant Hyperthermia in Pediatric Surgery: Essential Awareness and Crisis Management.
J Pediatr Surg
December 2024
Department of Pediatric Surgery, NewYork-Presbyterian/Morgan Stanley Children's Hospital, New York, NY, USA.
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