To investigate the correlation between impulse oscillometry system examination indicators and conventional pulmonary ventilation function. The pulmonary ventilation function data of 10 883 patients from January 1, 2020 to December 31, 2022 at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology were included. The one-second rate [ratio of forced expiratory volume in the first second (FEV) to forced vital capacity (FVC)] measured as a percentage of the predicted value was ≥92% for the control group (3 478) and <92% for the pulmonary obstruction group (7 405). The obstruction group was subdivided into five groups according to the degree of pulmonary dysfunction: mild group (3 938),moderate group (1 142),oderate-severe group (917),severe group (737),and extremely severe group (671). Conventional pulmonary ventilatory function FVC, FEV, one-second rate, and forced expired flow at 50% of FVC (MEF50%), forced expired flow at 75% FVC (MEF25%), maximal mid-expiratory flow (MMEF), peak expiratory flow (PEF), and pulsed oscillation pulmonary function test were detected in both groups of patients. Impedance at 5 Hz (Z5) means total respiratory resistance, resistance at 5 Hz (R5) means total airway resistance, reactance at 5 Hz (X5) indicates the elastic recoil of the peripheral airways, and resistance at 20 Hz (R20) represents resistance of the central airways. R5-R20 reflects resistance in the small airways. Additionally, peripheral resistance (Rp), respiratory resonance frequency (Frex), and area under the reactance curve (Ax) were also measured. Correlation between the indicators of the two groups and the sensitivity and specificity of the impulse oscillometry system parameters for the diagnosis of obstructive pulmonary ventilation dysfunction were analyzed. Pulmonary function force expiratory volume in the first second as a percentage of predicted value (FEV%Pre) [80.10 (54.95,97.10)%],one-second rate [62.43(48.67, 67.02)%],MEF50% [1.33 (0.62,1.97)L/s],MEF25% [0.28 (0.17,0.41)L/s], MMEF [0.85 (0.43,1.29)L/s],and PEF [5.64 (3.73,7.50)]L/s in the obstruction group were significantly lower than those in the control group (0.05). The differences within the subgroups of the obstruction group were also significant (0.05). Pulsed oscillation Z5 [0.42 (0.33,0.55)kPa·L·s],Rp [0.25 (0.20,0.45)kPa·L·s], R5 [0.39 (0.31,0.49)kPa·L·s], R20 [0.28 (0.24,0.34)kPa·L·s], R5-R20 [0.09 (0.05,0.17)kPa·L·s],Frex [16.32 (13.07,20.84)Hz], and Ax [0.67 (0.28,1.64)] indices in the obstruction group were significantly higher than those in the control group. X5 [-0.14 (-0.23, -0.10)kPa·L·s] was significantly lower than that in the control group (0.05). Z5, Rp, X5, R5, R5-R20, Frex, and Ax were statistically significant between different degrees of obstruction in the obstruction group (0.05). The impulse oscillometry system parameters Z5, Rp, R5, R20, R5-20, Frex, and Ax were negatively correlated with the indices of conventional pulmonary ventilation (=-0.21-0.68, 0.05), and the parameter X5 was positively correlated with the indices of conventional pulmonary ventilation (0.41-0.68, 0.05). The pulsed oscillation pulmonary function test parameters X5 (58.60%-95.68%) and Ax (57.08%-98.06%) presented the best sensitivity; X5 (86.29%-98.82%), Frex (86.69%-94.71%), and Ax (88.10%-98.53%) displayed the best specificity; and R20 presented the worst sensitivity and specificity. The sensitivity and specificity were slightly better in female patients than in male patients. The technical parameters of the impulse oscillometry system showed significant correlation with relevant indices of conventional pulmonary ventilation function detection. These well reflect the changes of different degrees of pulmonary ventilation function and have greater significance for reference in evaluating the degree of pulmonary function impairment.
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http://dx.doi.org/10.3760/cma.j.cn112138-20240410-00231 | DOI Listing |
BMC Pulm Med
December 2024
Department of Endocrinology and Metabolism, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518033, China.
J Allergy Clin Immunol
December 2024
Pulmonary, Critical Care, and Sleep Medicine, University of Kansas Medical Center. Electronic address:
Modern pulmonary imaging can reveal underlying pathological and pathophysiological changes in the lungs of people with asthma, with important clinical implications. A multitude of imaging modalities are now used to examine underlying structure/function relationships including computed tomography, magnetic resonance imaging, optical coherence tomography, and endobronchial ultrasound. Imaging-based biomarkers from these techniques, including airway dimensions, blood vessel volumes, mucus scores, ventilation defect extent and air trapping extent, often have increased sensitivity compared to traditional lung function measurements, and are increasingly used as endpoints in clinical trials.
View Article and Find Full Text PDFBMC Pulm Med
December 2024
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
Background: Despite the significant prevalence of chronic obstructive pulmonary disease (COPD) in Southwest China, cognitive function among middle-aged and elderly individuals in this area surpasses the national average. This study aims to reveal the overall pulmonary ventilation function status of this population, and investigate whether pulmonary ventilation dysfunction is a risk factor for mild cognitive impairment (MCI) in this region, as suggested by previous researches.
Methods: Data were obtained from the 2019-2021 baseline survey of a natural population cohort study conducted in Southwest China.
J Clin Anesth
December 2024
Department of Anaesthesiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Department of Anaesthesiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Background: Patients receiving intraoperative ventilation during general anesthesia often have low end-tidal CO (etCO). We examined the association of intraoperative etCO levels with the occurrence of postoperative pulmonary complications (PPCs) in a conveniently-sized international, prospective study named 'Local ASsessment of Ventilatory management during General Anesthesia for Surgery' (LAS VEGAS).
Methods: Patients at high risk of PPCs were categorized as 'low etCO' or 'normal to high etCO' patients, using a cut-off of 35 mmHg.
Medicine (Baltimore)
December 2024
Department of Respiratory and Critical Care Medicine, Siping Central People's Hospital, Siping, Jilin, China.
Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory condition with high morbidity and mortality. Noninvasive mechanical ventilation (NIV) is often used to manage acute COPD exacerbations, but failure can lead to worse outcomes. This systematic review aimed to evaluate risk prediction models for NIV failure in patients with COPD.
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