AI Article Synopsis
- The older population makes up about 50%-60% of newly diagnosed cancer patients, making it essential to consider their specific healthcare needs.
- Older patients face higher risks of severe side effects from cancer treatments due to age-related factors and existing health conditions, leading to often being under-treated.
- The review highlights the importance of understanding cancer drug pharmacology and advocating a cautious treatment approach to minimize dangerous toxicities in older patients.
Article Abstract
The older population represents ∼50%-60% of the population of newly diagnosed patients with cancer. Due to physiological and pathological aging and the increased presence of comorbidities and frailty factors, this population is at higher risk of serious toxicity from anticancer drugs and, consequently, often under-treated. Despite the complexity of these treatments, a good knowledge of the pharmacology of anticancer drugs and potentially risky situations can limit the emergence of potentially lethal toxicities in this population. This review focuses on optimizing systemic oncology treatments for older patients, emphasizing the unique characteristics of each therapeutic class and the necessity for a precautionary approach for this vulnerable population.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567126 | PMC |
| http://dx.doi.org/10.1016/j.esmoop.2024.103965 | DOI Listing |
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