Objective: This study was conducted as a randomized controlled double-blind trial to examine the effects of massage and bathing using lavender oil on the pain, stress, and behavior of newborns. It was hypothesized that the interventions would be associated with changes in pain, stress, and behavior in newborns.
Methods: The sample of the study included 45 term newborns (15 lavender massage groups, 15 lavender bath groups, 15 control groups). Newborns with a postnatal age of 1-5 days and a gestational age of 38-42 weeks, who could tolerate enteral nutrients, were not connected to a respiratory support device, had no skin disease, had no genetic or chromosomal abnormalities, did not undergo surgical intervention, and at least one parent giving written consent were included in the study. Descriptive statistics, chi-square, repeated measures ANOVA, and one-way ANOVA tests were used to evaluate the data.
Results: It was determined that the Neonatal Pain and Stress Rating Scale scores of the newborns in the lavender massage group decreased at the 5th minute after the study compared to before the study. It was determined that the Anderson Behavior Status Scoring System scores of the newborns in the lavender massage group decreased at the 5th minute after the study compared to before the study. It was also determined that the mean difference between the Neonatal Pain and Stress Rating Scale scores of the newborns in the lavender massage group was higher than the other groups.
Conclusion: Aromatherapy massage with lavender oil is more effective in reducing pain and stress levels and improving behavioral outcomes in newborns than a bath application using lavender oil.
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Adv Clin Chem
January 2025
Center for Orphan Drug Research, Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN, United States. Electronic address:
Gaucher disease (GD) is a rare lysosomal disorder characterized by the accumulation of glycosphingolipids in macrophages resulting from glucocerebrosidase (GCase) deficiency. The accumulation of toxic substrates, which causes the hallmark symptoms of GD, is dependent on the extent of enzyme dysfunction. Accordingly, three distinct subtypes have been recognized, with type 1 GD (GD1) as the common and milder form, while types 2 (GD2) and 3 (GD3) are categorized as neuronopathic and severe.
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January 2025
Department of Psychology, University of Southern Denmark, Odense, Denmark; Specialized Hospital for Polio and Accident Victims, Rødovre, Denmark.
Posttraumatic stress disorder (PTSD) is a common comorbidity to chronic pain, among others due to potentially shared posttraumatic origin. There has been growing interest in this field in the past decades, also providing some important studies to support our understanding of this comorbidity and how to address it in clinical practice. However, there are still important questions, particularly regarding the potentially shared vulnerabilities, mutually maintaining mechanisms, and how to best treat this comorbidity.
View Article and Find Full Text PDFCNS Neurosci Ther
January 2025
Department of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Objectives: Endoplasmic reticulum (ER) stress-induced protein homeostasis perturbation is a core pathological element in the pathogenesis of neurodegenerative diseases. This study aims to clarify the unique role played by C/EBP homologous protein (CHOP) as a biomarker of the unfolded protein response (UPR) in the etiology of chronic pain and related cognitive impairments following chronic constrictive nerve injury (CCI).
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Curr Mol Med
January 2025
Department of Anesthesiology, Baoan Central Hospital of Shenzhen, Shenzhen, Guangdong Province, China.
Background: Morphine, a mu-opioid receptor (MOR) agonist commonly utilized in clinical settings alongside chemotherapy to manage chronic pain in cancer patients, has exhibited contradictory effects on cancer, displaying specificity toward certain cancer types and doses.
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Digit Health
January 2025
Division of Rheumatology, Department of Medicine (DMED), ASUFC, University of Udine, Udine, Italy.
Background: Immersive Virtual Reality (VR) has been applied in pain management for various conditions, but its use in fibromyalgia (FM) remains underexplored. While physical activity plays a role in treating FM, patients' low tolerance often limits its effectiveness. After reviewing the literature on VR and games for FM, we designed a novel VR exergame to assist FM patients in performing physical activity, and evaluate its feasibility.
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