AI Article Synopsis
- Alcaligenes sp., typically known as an environmental contaminant, is increasingly found in clinical infections, with a focus on the strain Alcaligenes nematophilus EBU-23 from a hospitalized infant in Nigeria.
- The strain exhibits resistance to various antibiotics, including β-lactams, cephalosporins, and fluoroquinolones, indicating significant treatment challenges.
- Genomic analysis reveals the presence of beta-lactam hydrolase and multidrug efflux genes, suggesting mechanisms for its resistance, marking this as the first whole-genome sequencing report of a multidrug-resistant A. nematophilus associated with childhood gastroenteritis in Nigeria.
Article Abstract
Although an environmental contaminant, Alcaligenes sp. are now increasingly reported in clinical infections. Here, we present a whole-genome sequence of an extended spectrum beta-lactamase (ESBL) Alcaligenes nematophilus strain EBU-23 encoding beta-lactamase, bla gene, isolated from the stool of a hospitalized infant with acute gastroenteritis in a tertiary hospital in Nigeria. Antibiotics susceptibility test revealed that the isolate was resistant to the β-lactams, cephalosporins, and penicillin, β-lactam combination, and the fluoroquinolones. Genomic analysis exposed the presence of a class A beta-lactam hydrolase gene and multiple multidrug efflux permease which may be responsible for the beta-lactamase and multidrug resistance observed with the isolate. To the best our knowledge, we describe the first whole-genome sequence of a multidrug-resistant A. nematophilus implicated in acute childhood gastroenteritis in Nigeria.
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| http://dx.doi.org/10.1007/s00284-024-03966-5 | DOI Listing |
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