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Faricimab efficacy in type 1 macular neovascularization: AI-assisted quantification of pigment epithelium detachment (PED) volume reduction over 12 months in Naïve and switch eyes.
Int J Retina Vitreous
January 2025
Fondation Asile des Aveugles, Department of Ophthalmology, Jules-Gonin Eye Hospital, University of Lausanne, Avenue de France 54, Lausanne, 1001, Switzerland.
Background: This study evaluates the efficacy of intravitreal Faricimab in reducing pigment epithelium detachment (PED) and fluid volumes in both treatment-naïve eyes and eyes unresponsive to anti-VEGF mono-therapies, all diagnosed with type 1 macular neovascularization (T1 MNV) over a period of 12-month.
Methods: A retrospective, single-center cohort study was conducted at the Jules Gonin Eye Hospital, Lausanne, Switzerland. Clinical records of treatment-naïve and non-responder switch patients presenting T1 MNV secondary to neovascular age-related macular degeneration (nAMD) from September 2022 to March 2023 were reviewed.
Construction of a nursing management program for early fluid resuscitation in patients with acute pancreatitis: a Delphi study in China.
BMC Nurs
January 2025
General Surgery Department, Tongji Shanxi Hospital, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, 99 Longcheng street, Taiyuan, 030032, Shanxi province, China.
Aim And Objectives: To construct a set of scientific and feasible nursing management protocols for early fluid resuscitation in acute pancreatitis (AP) patients that can be used to guide clinical practice and enhance the treatment efficacy in these patients.
Background: Fluid resuscitation is a key means of early treatment for AP patients and has become a clinical consensus. Nurses are important practitioners of fluid resuscitation, and there is a lack of specific enforceable nursing management programs.
Biomarkers.
Alzheimers Dement
December 2024
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Centro de Neurociencias, Panamá, Panamá, Panama.
Background: By 2025, an estimated three-quarters of the global population aged 60 and older will live in Latin American and Caribbean countries (LAC), leading to a rise in age-related conditions. The main goal of the Panama Aging Research Initiative - Health Disparities (PARI-HD) research program is to create a platform for multidisciplinary clinical studies that focus on mental health and its diseases such as age-related cognitive decline. This platform would generate a large amount of clinical, neuropsychological, lifestyle, genetic and biomarker data following standardized research protocols.
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Alzheimers Dement
December 2024
Osaka University Graduate School of Medicine, Toyonaka, Japan.
Background: We have developed a technology for isolating extracellular vesicles (EVs) released from the central nervous system present in plasma.
Method: Initially, we differentiated induced pluripotent stem cells (iPS) into neurons to examine the membrane surface molecules of neuron-derived EVs in culture media. Our analysis revealed a specific interest in neuron-specific APLP1.
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Alzheimers Dement
December 2024
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, CA, USA.
Background: Amyloid-β (Aβ) plaques and tau pathogenesis in the brain precede cognitive decline in the progression of Alzheimer's dementia, yet the extent to which these measures can predict localized brain tissue atrophy has not been studied in a large, diverse population. Multisite studies offer robust statistical power with larger sample sizes but are confounded by variations in biomarker quantification across studies, including variations in MRI scanners, PET tracers, and CSF assays. Longitudinal data from N=1223 individuals from four independent AD studies were harmonized to assess localized brain tissue atrophy over 2 to 5 years.
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