ECPELLA in Advanced Cardiogenic Shock: Venting for Anyone?

ASAIO J

From the The CardioVascular Center, Tufts Medical Center, Boston, Massachusetts.

Published: November 2024

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http://dx.doi.org/10.1097/MAT.0000000000002332DOI Listing

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Article Synopsis
  • * Among 996 patients analyzed, those using the Impella 5.0/5.5 had significantly lower 30-day mortality rates compared to those using the smaller Impella 2.5/CP devices.
  • * The findings suggest that using the larger Impella 5.5 or upgrading from the smaller model could improve survival rates in patients with advanced AMI-CS on ECPELLA support.
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Article Synopsis
  • The study investigates the outcomes of different Mechanical Circulatory Support (MCS) devices, specifically comparing ECMO and Impella, in patients with cardiogenic shock due to acute myocardial infarction (AMI-CS).
  • Data from the national readmission database revealed that the majority of patients received Impella, while the ECMO group was generally younger with fewer health issues.
  • Despite advances in MCS technologies, there was no significant change in mortality rates for AMI-CS between 2016 and 2020, and ECMO had higher adverse outcomes compared to Impella, indicating a need for further research.
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ECPELLA Mixing Cloud on Computed Tomography Angiogram.

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January 2025

Department of Critical Care Medicine, and Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida.

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The utilization of temporary mechanical circulatory support (MCS) in the management of cardiogenic shock is experiencing a notable surge. Acute myocardial infarction remains the predominant etiology of cardiogenic shock, followed by heart failure. Recent findings from the DanGer Shock trial indicate that the percutaneous micro-axial flow pump support, in conjunction with standard care, significantly reduced 6-month mortality in patients with acute myocardial infarction-related cardiogenic shock compared to those receiving standard care alone.

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