Oxygen Concentration Effect in Photosensitized Generation of O from Normoxia to Hypoxia.

J Phys Chem Lett

Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology and Center for Biomedical Optics and Molecular Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Published: November 2024

Photodynamic therapy (PDT) has gained widespread acceptance as a clinical cancer treatment modality and has been attracting intensive attention on developing novel PDT strategies. However, the hypoxic environment in tumors is considered as a significant challenge for efficient type II PDT, based on the inference of the highly oxygen-concentration-related O generation. Contrary to this conventional understanding, our research demonstrates oxygen concentration independence in the photosensitized generation of O, as evidenced through steady-state and transient spectroscopy for chlorin e6 and methylene blue from normoxic to hypoxic conditions. We propose an oxygen-concentration-independent kinetic model, suggesting that efficient O generation can take place as long as the triplet-state lifetime ratio of the photosensitizer (τ/τ) is in a similar range to pO/pO. Our findings provide insights into PDT mechanisms and indicate that the oxygen concentration reduction concerns may not be critical for effective PDT in hypoxic tumor environments.

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Source
http://dx.doi.org/10.1021/acs.jpclett.4c02547DOI Listing

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