In this study, a novel label-free fluorescent aptasensor with an aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen (CEA). The sensor has a simple detection mechanism, easy operation, high sensitivity (with low limit of detection of 1 pg mL), good selectivity, and wide linear range (0.003-10 ng mL). In addition, it can be directly applied for the determination of CEA in human serum.
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