AI Article Synopsis
- A high-fat diet (HFD) has been identified as a significant factor contributing to inflammatory bowel disease (IBD), but the exact mechanisms remain unclear.
- The study utilized 16S rRNA-sequencing and RNA-seq technology on mice to uncover how HFD influences gut microbiota and gene expression related to IBD.
- Key findings revealed changes in gut microbiota and discovered 11 important hub genes and 7 pathways linked to IBD, suggesting that HFD may promote colitis through intestinal dysbiosis and specific genes, highlighting potential therapeutic targets.
Article Abstract
A high-fat diet (HFD) is recognized as an important contributor to inflammatory bowel disease (IBD). However, the precise underlying mechanism of HFD on IBD remains elusive. This study aimed to investigate the potential mechanism by which HFD affects IBD using 16S rRNA-sequencing and RNA-seq technology. Results indicated that HFD-treated mice exhibited notable alternations in the structure and composition of the gut microbiota, with some of these alternations being associated with the pathogenesis of IBD. Analysis of the colon transcriptome revealed 11 hub genes and 7 hub pathways among control, DSS-induced colitis, and HFD + DSS-treated groups. Further analysis explores the relationship between the hub pathways and genes, as well as the hub genes and gut microbiota. Overall, the findings indicate that the impact of HFD on DSS-induced colitis may be linked to intestinal dysbiosis and specific genes such as , , , , , , , , , , and . These results provide valuable insights for determining potential therapeutic targets for addressing HFD-induced IBD.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521715 | PMC |
| http://dx.doi.org/10.1002/fsn3.4426 | DOI Listing |
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