Enhanced Creatinine Level in Diabetic Patients Maximizing the Possibilities of Nephropathy and Its Association With Blood Urea Nitrogen and Glomerular Filtration Rate.

Introduction: Diabetes mellitus is a common metabolic disorder that is sometimes responsible for kidney diseases, especially in the form of diabetic nephropathy. In this study, we tried to investigate the markers associated with kidney diseases within diabetic patients as compared to non-diabetic participants.

Methodology: In this study, among 237 participants, 81 patients were diabetic, whereas 156 were non-diabetic participants. The level and association of serum creatinine, blood urea nitrogen (BUN), and glomerular filtration rate (GFR) were investigated using the enzymatic method and CKD-EPI equation respectively.

Result: We found significantly higher creatinine and BUN levels and lower GFR in the diabetic group compared to the non-diabetic group. Besides, we determined a positive association between creatinine and BUN, and an inverse relationship between GFR and creatinine and BUN respectively which was highly scattered in the case as compared to the non-diabetic group. Further analysis of the participants with high creatinine levels only supported the main outcomes.  Conclusion: Our investigation of kidney markers suggests a significant association between diabetes and kidney complications. Leading a healthy lifestyle and maintaining blood sugar and pressure may help to slow down the progress of diabetic nephropathy for diabetic patients.