Synthesis of Starfish-Shaped ZnS Nanostructures by Hydrothermal Method and Their Electrochemical Sensing of Dopamine.

Introduction Dopamine serves an essential function as a neurotransmitter, influencing the regulation of movement, cognitive processes, and emotional states. The identification of abnormal dopamine levels is critical for clinical diagnoses and scientific research, given its links to various disorders, including depression, schizophrenia, and Parkinson's disease. The distinctive electrochemical characteristics, stability, and broad bandgap of zinc sulfide (ZnS) nanostructures render them particularly fascinating. The hydrothermal method is recognized as an effective and economical approach for the fabrication of ZnS nanostructures, exhibiting a range of morphologies. Utilizing this method to create ZnS nanostructures leads to the formation of structures characterized by extensive surface areas, hierarchical designs, and improved electrochemical properties. Aim The objective is to examine the electrochemical characteristics of ZnS starfish-shaped nanostructures produced through the hydrothermal technique and to assess their viability as a sensing platform for dopamine detection. Materials and methods To synthesize ZnS nanoflowers, stoichiometric amounts of transition metal salts were prepared: 10 mM of Zn(NO)•3HO and 30 mM of sodium thiosulfate (NaSO•5HO) were dissolved in 30 mL of deionized water and stirred for 20 minutes. The solutions were then combined and transferred into a 100 mL Teflon autoclave reactor, which was heated at 200 °C for 12 hours in a furnace. This process utilized the hydrothermal technique to produce the desired ZnS nanoflowers. Result The crystalline arrangement of ZnS was validated by X-ray diffraction (XRD) analysis, aligning with the Joint Committee on Powder Diffraction Standards (JCPDS). Moreover, field emission scanning electron microscopy (FE-SEM) illustrated the particle morphology of ZnS, showing a range between 200 and 500 nm size. Additionally, the cyclic voltammetry results indicated that the modified electrode produced a greater current response than the bare electrode, highlighting its improved sensitivity to dopamine molecules. Conclusion ZnS nanoparticles were synthesized via a hydrothermal method and characterized using XRD and FE-SEM. These nanoparticles were used for electrochemical dopamine detection, showing potential for advanced sensing platforms. Integrating ZnS into microfluidic devices enables real-time dopamine monitoring, opening new possibilities for healthcare and neurochemical research. Exploring surface engineering techniques could further enhance the electrochemical performance of ZnS-based sensors.