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Cerebrospinal fluid red blood cells and total protein are associated with clinical outcome in spontaneous subarachnoid hemorrhage. | LitMetric

AI Article Synopsis

  • This study investigates how cerebrospinal fluid (CSF) red blood cell (RBC) count and total protein (TP) concentration relate to outcomes in patients who have experienced spontaneous subarachnoid hemorrhage (SAH).
  • Conducted on patients in a neurological intensive care unit, the research measured CSF samples at various stages post-admission to identify predictive markers for recovery.
  • Results showed that lower levels of RBC and TP in the CSF correlated with better functional outcomes and survival rates in these SAH patients, highlighting the importance of these measurements in clinical prognosis.

Article Abstract

Background And Purpose: Prognostication in patients with spontaneous subarachnoid hemorrhage (SAH) can be challenging. The aim of this study was to assess whether cerebrospinal fluid (CSF) red blood cell (RBC) count and total protein (TP) concentration are associated with SAH prognosis.

Methods: Patients with SAH treated at the neurological intensive care unit (ICU) in Innsbruck were included in this real-world, observational study. Longitudinal CSF samples were collected as part of routine diagnostics. RBC count and CSF TP at the time of admission (RBC, TP), in Week 1 (RBC, TP), Week 2 (RBC, TP), and Week 3 or thereafter (RBC, TP), the highest detected value (RBC, TP), as well as the RBC count adjusted for disease duration (RBC) were assessed. Primary outcomes were good functional outcome after 3 months, defined as modified Rankin scale score ≤2 and ICU survival.

Results: A total of 183 SAH patients with a female predominance (69%), a median (interquartile range [IQR]) age of 60 (50-70) years and median (IQR) Hunt and Hess score of 4 (3-5) were included. Multivariable analyses revealed that lower values of RBC, RBC, RBC, TP and TP were associated with good functional outcome and hospital survival. Lower TP concentrations in Weeks 1, 2 and 3 were associated with good functional outcome, and in Weeks 1 and 2 with ICU survival. Early RBC measurements (Week 1) were associated with good functional outcome and ICU survival.

Conclusions: Low CSF RBC counts and TP concentrations were associated with good functional outcome and ICU survival in a real-world cohort of SAH patients requiring external ventricular drainage.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622267PMC
http://dx.doi.org/10.1111/ene.16456DOI Listing

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