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Drones delivering automated external defibrillators for out-of-hospital cardiac arrest: A scoping review.
Resusc Plus
January 2025
Emergency Medical Services, Capital Region of Denmark, Ballerup, Denmark.
Unlabelled: Out-of-hospital cardiac arrest (OHCA) remains a critical health concern, where prompt access to automated external defibrillators (AEDs) significantly improves survival. This scoping review broadly investigates the feasibility and impact of dronedelivered AEDs for OHCA response.
Methods: PubMed, Cochrane, and Web of Science were searched from inception to August 6, 2024, with eligibility broadly including empirical data.
Real-World Outcomes in Patients with Advanced Penile Squamous Cell Carcinoma Receiving Immune Checkpoint Inhibitors: A Single Institution Experience.
J Immunother Precis Oncol
February 2025
Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA, USA.
Introduction: Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with a poor prognosis and an unmet need for biomarkers. We performed a retrospective evaluation of real-world efficacy, safety outcomes, and baseline inflammatory biomarkers in patients with advanced pSCC treated with immune checkpoint inhibitors (ICIs).
Methods: We performed a retrospective review of patients with advanced pSCC who received ICIs from 2012 to 2023 at the Winship Cancer Institute of Emory University in Atlanta, GA.
MOANA: Multi-objective ant nesting algorithm for optimization problems.
Heliyon
January 2025
Centre for Artificial Intelligence Research and Optimisation, Torrens University, Brisbane, QLD, 4006, QLD 4006, Austral, Australia.
This paper presents the Multi-Objective Ant Nesting Algorithm (MOANA), a novel extension of the Ant Nesting Algorithm (ANA), specifically designed to address multi-objective optimization problems (MOPs). MOANA incorporates adaptive mechanisms, such as deposition weight parameters, to balance exploration and exploitation, while a polynomial mutation strategy ensures diverse and high-quality solutions. The algorithm is evaluated on standard benchmark datasets, including ZDT functions and the IEEE Congress on Evolutionary Computation (CEC) 2019 multi-modal benchmarks.
View Article and Find Full Text PDFBeyond bronchial thermoplasty - where to now?
EClinicalMedicine
January 2025
Department of Mathematics, University of Auckland, Auckland, New Zealand.
With the impending 'retirement' of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodelling.
View Article and Find Full Text PDFThe rise of weekly insulins: addressing the challenges of type 2 diabetes care in Brazil.
Diabetol Metab Syndr
January 2025
Serviço de Endocrinologia (SEMPR) do Hospital das Clínicas da Universidade Federal do Paraná (UFPR), Curitiba, Brazil.
Background: Type 2 diabetes mellitus (T2D) is a global health concern with a rising prevalence, particularly in Brazil. Insulin therapy plays a crucial role in managing T2D, helping to maintain glucose and energy homeostasis. Moreover, early initiation of insulin is crucial for hyperglycemic control and prevention of chronic complications.
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