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| http://dx.doi.org/10.1136/bmjpo-2024-002747 | DOI Listing |
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The effects of parental marital quality on preschool children's social-emotional competence: The chain mediating model of parent-child and sibling relationships.
Infant Ment Health J
November 2024
Faculty of Education, Northeast Normal University, Changchun, PR China.
With the swift advancements in China's education system and society, preschool children's social-emotional competence is becoming increasingly important for adapting to complicated situations. While research shows parental marital quality as a key factor, studies on its specific mechanisms within the Chinese context are limited. Grounded in the framework of family systems theory and incorporating perspectives from the spillover hypothesis, emotional security theory, and attachment theory, this research explores how parental marital quality influences preschool children's social-emotional competence, emphasizing the mediating roles of parent-child and sibling relationships in China.
View Article and Find Full Text PDFMultistate and functional protein design using RoseTTAFold sequence space diffusion.
Nat Biotechnol
September 2024
Department of Biochemistry, University of Washington, Seattle, WA, USA.
Protein denoising diffusion probabilistic models are used for the de novo generation of protein backbones but are limited in their ability to guide generation of proteins with sequence-specific attributes and functional properties. To overcome this limitation, we developed ProteinGenerator (PG), a sequence space diffusion model based on RoseTTAFold that simultaneously generates protein sequences and structures. Beginning from a noised sequence representation, PG generates sequence and structure pairs by iterative denoising, guided by desired sequence and structural protein attributes.
View Article and Find Full Text PDFVitrification preservation of good-quality blastocysts for more than 5 years reduces implantation and live birth rates.
Hum Reprod
September 2024
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, The People's Republic of China.
Study Question: Does vitrification cryopreservation of embryos for more than 5 years affect the pregnancy outcomes after frozen embryo transfer (FET)?
Summary Answer: Vitrification cryopreservation of good-quality blastocysts for more than 5 years is associated with a decrease in the implantation rate (IR) and live birth rate (LBR).
What Is Known Already: Previous studies have predominantly focused on embryos cryopreserved for relatively short durations (less than 5 years), yet the impact of extended cryopreservation duration on pregnancy outcomes remains a controversial issue. There is a relative scarcity of data regarding the efficacy and safety of storing embryos for 5 years or longer.
Under-5, infant, and neonatal mortality trends and causes of death, 1991-2022: Findings from death surveillance in Xicheng district of Beijing, China.
Prev Med Rep
December 2023
Xicheng District Maternal and Child Health Hospital, Beijing 100054, PR China.
Overall, China has made substantial progress in improving child survival over the past few decades, but a detailed understanding of child mortality trend at local level is limited. This study aimed to present a comprehensive analysis of under-5, infant, and neonatal mortality rates and its trend in Xicheng district of Beijing, China. We used the surveillance data of under-5 children reported by Preventive Health Department of Xicheng District Community Health Service Center from 1991 to 2022.
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