To enhance the understanding of flocculated sludge granulation, this study focused on a bacterial denitrification system using low-intensity ultrasound and inert particles to stimulate cell activity and facilitate flocculated sludge granulation. After 75 days, the activated carbon, activated carbon + ultrasonication, and microplastic + ultrasonication groups showed partial pelletization. Both ultrasound and inert particles promoted extracellular polymeric substance secretion and enhanced electron transport system activity. Low-intensity ultrasound improved denitrification performance and enhanced denitrifying bacteria. The addition of inert materials facilitated denitrifying flocculated sludge granulation. Low-intensity ultrasound combined with microplastics obtained the highest activity and enrichment of denitrifying bacteria in granular sludge. This study provides new ideas for optimizing anaerobic sludge granulation.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.biortech.2024.131724 | DOI Listing |
Bioengineering (Basel)
November 2024
Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
Exosomes are extracellular nanovesicles secreted by cells that efficiently deliver therapeutic cargo for cancer treatment. However, because exosomes are present in low quantities and have limited target specificity, internal and external stress stimulation has been studied to increase exosome efficiency. Inspired by these studies, the uptake efficiency of cobalt chloride-induced hypoxic cancer cell-secreted exosomes was evaluated.
View Article and Find Full Text PDFCancers (Basel)
December 2024
Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, 03-242 Warsaw, Poland.
Gliomas are a wide group of common brain tumors, with the most aggressive type being glioblastoma multiforme (GBM), with a 5-year survival rate of less than 5% and a median survival time of approximately 12-14 months. The standard treatment of GBM includes surgical excision, radiotherapy, and chemotherapy with temozolomide (TMZ). However, tumor recurrence and progression are common.
View Article and Find Full Text PDFCommun Biol
January 2025
Department of Physiology, New York Medical College, Valhalla, NY, USA.
Non-invasive, low intensity focused ultrasound is an emerging neuromodulation technique that offers the potential for precision, personalized therapy. An increasing body of research has identified mechanosensitive ion channels that can be modulated by FUS and support acute electrical activity in neurons. However, neuromodulatory effects that persist from hours to days have also been reported.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Neurosurgery and Brain Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Although low-intensity focused ultrasound (LiFUS) with microbubbles is used to temporally open the blood-brain barrier (BBB), the underlying mechanism is not fully understood. This study aimed to analyze BBB-related alterations in the brain microenvironment after LiFUS, with a focus on the involvement of the purinergic P × receptor. Sprague-Dawley rats were sonicated with LiFUS at 0.
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Neurology, NHO Suzuka Hospital, Suzuka, Japan.
Backgrounds: Intramuscular mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a low intensity and latency of antibody response in patients with muscular disorders (MDs). However, the mechanisms involved in this phenomenon remain unknown. This study aimed to clarify the mechanism of the low immunogenicity of intramuscular SARS-CoV-2 mRNA vaccination in patients with MDs.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!