AI Article Synopsis
- - Bacterial vaccines are essential for preventing infectious diseases and lowering death rates in affected groups, showcasing their critical role in public health.
- - Innovations like reverse vaccinology and bioinformatics are transforming vaccine design, particularly with the advancement of multi-epitope vaccines (MEVs) that target specific pathogens.
- - The review highlights the methods used in epitope vaccine development, recent advancements, and the challenges faced in creating genetically engineered multi-epitope vaccines for future applications.
Article Abstract
Bacterial vaccines play a crucial role in combating bacterial infectious diseases. Apart from the prevention of disease, bacterial vaccines also help to reduce the mortality rates in infected populations. Advancements in vaccine development technologies have addressed the constraints of traditional vaccine design, providing novel approaches for the development of next-generation vaccines. Advancements in reverse vaccinology, bioinformatics, and comparative proteomics have opened horizons in vaccine development. Specifically, the use of protein structural data in crafting multi-epitope vaccines (MEVs) to target pathogens has become an important research focus in vaccinology. In this review, we focused on describing the methodologies and tools for epitope vaccine development, along with recent progress in this field. Moreover, this article also discusses the challenges in epitope vaccine development, providing insights for the future development of bacterial multi-epitope genetically engineered vaccines.
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| http://dx.doi.org/10.1016/j.ijbiomac.2024.136827 | DOI Listing |
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