Purpose: To compare potential dose reduction and quality improvement in chest CT images with Photon-Counting CT (PCCT) versus a Dual-Source CT (DSCT).
Methods: Acquisitions on phantoms were performed on a DSCT and a PCCT at 5 dose levels (9.5/7.5/6.0/2.5/0.4 mGy). Noise power spectrum (NPS) and task-based transfer function (TTF) were calculated to assess noise magnitude and noise texture (f) and spatial resolution (f), respectively. Computed detectability indexes (d') modelled the detection of 2 chest lesions: subsolid pulmonary nodules (SPN) and high-contrast pulmonary nodules (HCN). Two radiologists subjectively assessed the quality of chest images on an anthropomorphic phantom.
Results: For all dose levels, noise magnitude was significantly lower with PCCT than with DSCT (-44.7 ± 3.0 %; p < 0.05). Identical outcomes were found for noise texture (f; -6.2 ± 0.5 %; p < 0.05). f values were significantly higher with DSCT than with PCCT from 9.5 to 6 mGy for iodine insert (p < 0.05) and from 7.5 to 2.5 mGy for air insert (p < 0.05), but similar for both inserts at other dose levels. For all dose levels, d' values were significantly higher with PCCT than DSCT (71.9 ± 5.4 % for HCN and 65.6 ± 13.5 % for SPN). From 9.5 to 2.5 mGy, the potential dose reduction was -59.0 ± 3.9 % for both lesions with PCCT compared to DSCT. Chest images were rated satisfactory for clinical use by the radiologists with both CTs for all dose levels, except at 0.4 mGy.
Conclusion: Noise magnitude and detectability of chest lesions were better with PCCT than with the DSCT. PCCT may offer great potential for dose reduction in patients undergoing chest CT examinations.
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http://dx.doi.org/10.1016/j.ejmp.2024.104844 | DOI Listing |
J Mol Histol
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Complementary and Integrative Medicine, Department of Traditional, Ankara Yıldırım Beyazıt University, Ankara, Türkiye, Turkey.
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μNEURO Research Centre of Excellence, Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.
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Department of Biochemistry & Molecular Biology, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
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Department of Science, De La Salle College, Institute of the Brothers of the Christian Schools, Toronto, Ontario, Canada.
Alcohol consumption is known to affect dopamine (DA) release in the brain, with significant implications for understanding addiction and its neurobiological underpinnings. This meta-analysis examined the effects of acute alcohol administration on striatal DA release in healthy humans as measured with [C]-raclopride positron emission tomography (PET). Oral alcohol administration was associated with a significant reduction in [C]-raclopride binding potential (BP) in the ventral striatum (Cohen's d = -0.
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The therapeutic benefit of the oral adsorbent drug AST-120 in chronic kidney disease (CKD) is related to an indoxyl sulfate (IS)-lowering action. Diabetes and dyslipidemia might worsen kidney damage in CKD. However, it is not known whether AST-120 influences lipid abnormalities as well as renal function in patients with CKD and diabetes.
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