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Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors.
Pharmaceutics
November 2024
Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Palbociclib, an oral CDK 4/6 inhibitor, was evaluated in a Pediatric Brain Tumor Consortium (PBTC) phase 1 (NCT02255461; PBTC-042) study to treat children and young adults with recurrent, progressive, or refractory brain tumors. The objectives of this study were to characterize the palbociclib population pharmacokinetics in children enrolled on PBTC-042, to conduct a population pharmacodynamic analysis in this patient population, and to perform a simulation study to assess the role of palbociclib exposure on neutropenia and thrombocytopenia. The palbociclib population pharmacokinetics and pharmacodynamics were characterized in this patient population (n = 34 patients; 4.
View Article and Find Full Text PDFAssociations between weather and malaria in an elimination setting in Peru: a distributed lag analysis.
medRxiv
November 2024
Department of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, USA.
Background: () is the predominant malaria species in countries approaching elimination. In the context of climate change, understanding environmental drivers of transmission can guide interventions, yet evidence is limited, particularly in Latin America.
Objectives: We estimated the association between temperature and precipitation and malaria incidence in a malaria elimination setting in Peru.
Population pharmacokinetics of rilpivirine following oral administration and long-acting intramuscular injection in real-world people with HIV.
Front Pharmacol
November 2024
Service of Clinical Pharmacology, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Article Synopsis
- The study investigates how long-acting rilpivirine functions in real-life clinical settings, addressing gaps left by clinical trials on its pharmacokinetics in people with HIV.
- Researchers analyzed data from 238 patients to establish concentration curves and identify factors influencing drug exposure, finding differences in absorption rates between genders but minimal clinical impact.
- The findings suggest that around 50% of rilpivirine concentrations meet the optimal therapeutic threshold, indicating potential variability in treatment effectiveness among patients.
PENGUIN: A rapid and efficient image preprocessing tool for multiplexed spatial proteomics.
Comput Struct Biotechnol J
December 2024
Department of Pathology, Leiden University Medical Centre, Leiden, the Netherlands.
Multiplex spatial proteomic methodologies can provide a unique perspective on the molecular and cellular composition of complex biological systems. Several challenges are associated to the analysis of imaging data, specifically in regard to the normalization of signal-to-noise ratios across images and subtracting background noise. However, there is a lack of user-friendly solutions for denoising multiplex imaging data that can be applied to large datasets.
View Article and Find Full Text PDFElimination of the Percentile Score From the Surgical ABSITE-The Program Director Perspective.
JAMA Surg
January 2025
Global Health Equity, Sacher Health Leadership Institute, Morehouse School of Medicine, Atlanta, Georgia.
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